Use of nanoparticles in the electrochemical analysis of biological samples

被引:16
作者
Vertelov, G. K. [1 ]
Olenin, A. Yu. [1 ]
Lisichkin, G. V. [1 ]
机构
[1] Moscow MV Lomonosov State Univ, Fac Chem, Moscow 119992, Russia
关键词
D O I
10.1134/S106193480709002X
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
The specific effects of various nanoparticles on processes occurring in the electrochemical analysis of biological samples are considered. The material classification is based on a structural principle of the organization of a sensing element. Nanoparticles can occur immediately on its surface or in the bulk of an analyte (in the latter case, they can be chemically bound to the surface); they can be incorporated into the analyte and serve as its labels. The use of nanoparticles significantly extends the capabilities of bioelectrochemical methods of analysis. In a number of cases, the use of nanoparticles provides an opportunity to abandon the use of enzymes; this is very promising for clinical analysis. Methods for the electrochemical analysis of biological samples with the use of nanoparticles can be a serious addition to classical biochemical methods.
引用
收藏
页码:813 / 824
页数:12
相关论文
共 114 条
[1]   Liposomes labeled with biotin and horseradish peroxidase: A probe for the enhanced amplification of antigen-antibody or oligonucleotide-DNA sensing processes by the precipitation of an insoluble product on electrodes [J].
Alfonta, L ;
Singh, AK ;
Willner, I .
ANALYTICAL CHEMISTRY, 2001, 73 (01) :91-102
[2]   Reactions of complex metalloproteins studied by protein-film voltammetry [J].
Armstrong, FA ;
Heering, HA ;
Hirst, J .
CHEMICAL SOCIETY REVIEWS, 1997, 26 (03) :169-179
[3]   Gold nanoparticle-based quantitative electrochemical detection of amplified human cytomegalovirus DNA using disposable microband electrodes [J].
Authier, L ;
Grossiord, C ;
Brossier, P ;
Limoges, B .
ANALYTICAL CHEMISTRY, 2001, 73 (18) :4450-4456
[4]  
Balavoine F, 1999, ANGEW CHEM INT EDIT, V38, P1912, DOI 10.1002/(SICI)1521-3773(19990712)38:13/14<1912::AID-ANIE1912>3.0.CO
[5]  
2-2
[6]   A novel electrochemical detection method for aptamer biosensors [J].
Bang, GS ;
Cho, S ;
Kim, BG .
BIOSENSORS & BIOELECTRONICS, 2005, 21 (06) :863-870
[7]   Improvement of poly(amphiphilic pyrrole) enzyme electrodes via the incorporation of synthetic laponite-clay-nanoparticles [J].
Besombes, JL ;
Cosnier, S ;
Labbe, P .
TALANTA, 1997, 44 (12) :2209-2215
[8]   DNA-templated assembly and electrode attachment of a conducting silver wire [J].
Braun, E ;
Eichen, Y ;
Sivan, U ;
Ben-Yoseph, G .
NATURE, 1998, 391 (6669) :775-778
[9]  
Budnikov G.K., 2003, Fundamentals of Modern Electrochemical Analysis
[10]   Electrochemical detection of DNA hybridization based on silver-enhanced gold nanoparticle label [J].
Cai, H ;
Wang, YQ ;
He, PG ;
Fang, YH .
ANALYTICA CHIMICA ACTA, 2002, 469 (02) :165-172