Metal-Free Synthesis of Furocoumarins: An Approach via Iodine-Promoted One-Pot Cyclization between 4-Hydroxycoumarins and Acetophenones

被引：14

作者：

Pham, Phuc H. ^{[1
]}

Nguyen, Que T. D. ^{[1
]}

Tran, Nhu K. Q. ^{[1
]}

Nguyen, Vu H. H. ^{[1
]}

Doan, Son. H. ^{[1
]}

Ha, Hiep Q. ^{[1
]}

Thanh Truong ^{[1
]}

Phan, Nam T. S. ^{[1
]}

机构：

[1] HCMC Univ Technol, VNU HCM, Fac Chem Engn, 268 Ly Thuong Kiet,Dist 10, Ho Chi Minh City, Vietnam

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2018年 / 2018卷 / 32期

关键词：

Furocoumarins; 4-Hydroxycoumarins; Acetophenones; One-pot; Tandem reaction; FACILE SYNTHESIS; DERIVATIVES; KETONES; ACCESS;

D O I：

10.1002/ejoc.201800983

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A transition metal-free approach was developed to achieve substituted furocoumarins via an iodine-promoted one-pot cyclization between 4-hydroxycoumarins and acetophenones. High yields of furocoumarins were achieved in the presence of NH4OAc as an additive, while neither acidic nor basic additives were effective. The reaction would proceed via a 5-exo-tet cyclization but not an O-alkylation. The fact that commercially available starting materials could be used without the need of a transition metal catalyst could be a significant advantage.

引用

收藏

页码：4431 / 4435

页数：5

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