Thymidine Kinase 1 is a Potential Marker for Prognosis and Monitoring the Response to Treatment of Patients with Breast, Lung, and Esophageal Cancer and Non-Hodgkin's Lymphoma

被引：44

作者：

He, E. ^{[1
]}

Xu, X. H. ^{[2
]}

Guan, H. ^{[3
]}

Chen, Y. ^{[4
]}

Chen, Z. H. ^{[5
]}

Pan, Z. L. ^{[6
]}

Tang, L. L. ^{[7
]}

Hu, G. Z. ^{[8
]}

Li, Y. ^{[1
]}

Zhang, M. ^{[1
]}

Zhou, J. ^{[1
]}

Eriksson, S. ^{[9
]}

Fornander, T. ^{[10
]}

Skog, S. ^{[1
]}

机构：

[1] Sino Swed Mol Biomed Res Inst, Shenzhen 518057, Peoples R China

[2] Zhejiang Canc Hosp, Dept Clin & Lab Med, Hangzhou, Zhejiang, Peoples R China

[3] Shenzhen Second Hosp, Dept Pathol, Shenzhen, Peoples R China

[4] Fujian Canc Hosp, Lab Biochem & Mol Biol Res, Fuzu, Peoples R China

[5] Third Xiangya Hosp, Ctr Hlth, Changsha, Hunan, Peoples R China

[6] 411 Hosp PLA, Dept Hematol, Shanghai, Peoples R China

[7] First Xiangya Hosp, Dept Breast, Changsha, Hunan, Peoples R China

[8] Jiangxi Peoples Hosp, Nanchang, Peoples R China

[9] Swedish Univ Agr Sci, Biomed Ctr, Dept Anat Physiol & Biochem, Uppsala, Sweden

[10] Karolinska Univ Hosp, Dept Oncol, Stockholm, Sweden

来源：

NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS | 2010年 / 29卷 / 4-6期

关键词：

Thymidine kinase 1; serum; immunohistochemistry; malignancies; ANTIBODY; PEPTIDE; SERUM;

D O I：

10.1080/15257771003738535

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Thymidine kinase 1 (TK1) is converting thymidine to thymidine monophosphate, and is related to DNA replication and cell proliferation. The use of the TK1 protein levels as a proliferation marker in malignancies is here summarized. TK1 protein in serum (STK1p) and TK1 expression in tissues were determined by a chemoluminescent dot blot assay and by immunohistochemistry staining, respectively. The expression of TK1 in tumor tissues correlated to pathological stages and clinical grades of carcinomas (ca) of esophagus, lung and in premalignancy of breast ductal ca. STK1p could monitor the out-come of tumor therapy by being correlated to remission [breast ca, non-Hodgkin's lymphoma], relapse [breast ca] and to survival [non-Hodgkin's lymphoma] of patients. In a health screening study of 12,641 persons, STK1p seemed to predict the risk of development of neoplasia related diseases at early stage.

引用

页码：352 / 358

页数：7

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