A Highly Efficient, Practical, and General Route for the Synthesis of (R3P)2Pd(0): Structural Evidence on the Reduction Mechanism of Pd(II) to Pd(0)

被引：60

作者：

Li, Hongbo ^{[1
]}

Grasa, Gabriela A. ^{[1
]}

Colacot, Thomas J. ^{[1
]}

机构：

[1] Johnson Matthey Catalysis & Chiral Technol, W Deptford, NJ 08066 USA

来源：

ORGANIC LETTERS | 2010年 / 12卷 / 15期

关键词：

PALLADIUM(II) HYDRIDE COMPLEXES; CATALYZED COUPLING REACTIONS; ARYL CHLORIDES; OXIDATIVE ADDITION; ROOM-TEMPERATURE; SONOGASHIRA REACTIONS; DIENE COMPLEXES; BROMIDES; COPPER; REACTIVITY;

D O I：

10.1021/ol101106z

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A highly efficient, practical, and general method was developed to synthesize a family of (R3P)(2)Pd(0) complexes, using a stoichlometric amount of phosphine ligands and readily available Pd(II) precursors. The stepwise pathway of reducing Pd(II) to Pd(0) was established by isolating two key intermediates. Both [t-Bu-2(4-Me2NC6H4)P](2)Pd and (t-Bu2NpP)(2)Pd are new compounds. Preliminary studies on [t-Bu-2(4-Me2NC6H4)P](2)Pd have indicated that It is a very active catalyst (84-95% Isolated yield) in the Cu-free Sonogashira coupling involving aryl and heteroaryl chlorides at 0.5 mol % catalyst loading.

引用

页码：3332 / 3335

页数：4

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