Toxicometabolomics: Small Molecules to Answer Big Toxicological Questions

被引：32

作者：

Araujo, Ana Margarida ^{[1
,2
]}

Carvalho, Felix ^{[1
,2
]}

Guedes de Pinho, Paula ^{[1
,2
]}

Carvalho, Marcia ^{[1
,2
,3
,4
]}

机构：

[1] Univ Porto, Inst Hlth & Bioecon, Associate Lab i4HB, Fac Pharm, P-4050313 Porto, Portugal

[2] Univ Porto, Dept Biol Sci, UCIBIO Appl Mol Biosci Unit, REQUIMTE,Lab Toxicol,Fac Pharm, Rua Jorge Viterbo Ferreira 228, P-4050313 Porto, Portugal

[3] Univ Fernando Pessoa, FP ENAS, FP I3ID, Praca 9 Abril 349, P-4249004 Porto, Portugal

[4] Univ Fernando Pessoa, Fac Hlth Sci, Rua Carlos Maia 296, P-4200150 Porto, Portugal

来源：

METABOLITES | 2021年 / 11卷 / 10期

关键词：

toxicometabolomics; drug toxicity; toxicity pathways; biomarkers; prediction models; SPECTROMETRY-BASED METABOLOMICS; PATTERN-RECOGNITION METHODS; MASS-SPECTROMETRY; CELL-CULTURE; INDUCED HEPATOTOXICITY; UNTARGETED METABOLOMICS; STATISTICAL-ANALYSIS; METABOLITE PROFILES; SAMPLE-PREPARATION; MAMMALIAN-CELLS;

D O I：

10.3390/metabo11100692

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Given the high biological impact of classical and emerging toxicants, a sensitive and comprehensive assessment of the hazards and risks of these substances to organisms is urgently needed. In this sense, toxicometabolomics emerged as a new and growing field in life sciences, which use metabolomics to provide new sets of susceptibility, exposure, and/or effects biomarkers; and to characterize in detail the metabolic responses and altered biological pathways that various stressful stimuli cause in many organisms. The present review focuses on the analytical platforms and the typical workflow employed in toxicometabolomic studies, and gives an overview of recent exploratory research that applied metabolomics in various areas of toxicology.

引用

页数：31

共 158 条

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