Voltage-gated sodium channels mutations and their role in epilepsy

被引：0

作者：

Patyra, Andrzej ^{[1
,2
,3
]}

Witkowski, Grzegorz ^{[4
]}

机构：

[1] Med Univ Warsaw, Dept Pharmacognosy & Mol Basis Phytotherapy, Warsaw, Poland

[2] Med Univ Warsaw, Warsaw, Poland

[3] Univ Montpellier, CNRS, Inst Biomole Max Mousseron, ENSCM, Montpellier, France

[4] Inst Psychiat & Neurol, Dept Neurol 1, Warsaw, Poland

来源：

BIULETYN WYDZIALU FARMACEUTYCZNEGO WARSZAWSKIEGO UNIWERSYTETU MEDYCZNEGO | 2022年 / 01期

关键词：

Voltage-gated sodium channel; Epilepsy; Dravet syndrome; GEFS+; SCN1A; FEBRILE SEIZURES PLUS; SEVERE MYOCLONIC EPILEPSY; GENERALIZED EPILEPSY; NA+; SUBUNIT; SCN1A; CHANNELOPATHIES; MECHANISMS; NA(V)1.2; PATIENT;

D O I：

暂无

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Voltage-gated ion channels play a pivotal role in cell signaling. They are responsible for generating action potential and repolarization. For this reason, dysfunctions of these channels are more and more often associated with the occurrence of both congenital and acquired neurological diseases, such as epilepsies, migraines, ataxias, or neuromyotonia. Clinical symptoms of neuronal ion channel dysfunction differ significantly, reflecting the role and distribution of a given channel in the central and peripheral nervous systems. This paper reviews voltage-gated sodium channel structure, physiology, mutations, and their role in epilepsy.

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页数：8

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