Differential expression of Toll-like receptor mRNA in White Leghorn and indigenous chicken of India

被引：26

作者：

Ramasamy, Kannaki T. ^{[1
]}

Reddy, Maddula R. ^{[1
]}

Raveendranathan, Dhanutha N. ^{[1
]}

Murugesan, Shanmugam ^{[1
]}

Chatterjee, Rudra N. ^{[1
]}

Ullengala, Rajkumar ^{[1
]}

Haunshi, Santosh ^{[1
]}

机构：

[1] Project Directorate Poultry, Hyderabad 500030, Andhra Pradesh, India

来源：

VETERINARY RESEARCH COMMUNICATIONS | 2010年 / 34卷 / 07期

关键词：

Toll-like receptor; White Leghorn; Indigenous chicken; Realtime PCR; NAKED NECK GENE; ENTERICA SEROVAR TYPHIMURIUM; FUNCTIONAL-CHARACTERIZATION; TROPICAL INTEREST; STRANDED-RNA; SUSCEPTIBILITY; IDENTIFICATION; RECOGNITION; TLR4; IMMUNOCOMPETENCE;

D O I：

10.1007/s11259-010-9431-0

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

In the present experiment, the expression profile of Toll-like receptor mRNA in indigenous and pure line chickens was studied. The expression of TLR3, TLR4, TLR5 and TLR7 were quantified in heterophils of Aseel, Kadaknath, Naked neck, Dwarf and White Leghorn lines by Quantitative Real-time PCR. White Leghorns expressed significantly (P < 0.01) higher levels of TLR3 mRNA compared to other lines. TLR4 and TLR5 mRNA were significantly highly expressed in Kadaknath line. Among the TLRs investigated TLR5 was more expressed in all lines studied. TLR7 was highly expressed in indigenous chicken Aseel and Kadaknath than other lines. Dwarf chicken expressed significantly (P < 0.01) lower levels of all TLRs investigated. On the basis of the present study we conclude that the differential expression of TLR mRNA in the heterophils of indigenous and other chicken breeds might contribute to their variable disease resistance/susceptibility.

引用

页码：633 / 639

页数：7

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