Fundamental aspects of solid dispersion technology for poorly soluble drugs

被引：421

作者：

Huang, Yanbin ^{[1
]}

Dai, Wei-Guo ^{[2
]}

机构：

[1] Tsinghua Univ, Dept Chem Engn, Key Lab Adv Mat MOE, Beijing 100084, Peoples R China

[2] Johnson & Johnson Co, Janssen Res & Dev, Randor, PA 19087 USA

来源：

ACTA PHARMACEUTICA SINICA B | 2014年 / 4卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Solid dispersion; Poorly soluble drug; Phase separation; Drug-polymer interaction; CRYSTAL-GROWTH; MELT EXTRUSION; PRECIPITATION; POLYMERS; BEHAVIOR; MISCIBILITY; SOLUBILITY; SUPERSATURATION; CRYSTALLIZATION; SULFATHIAZOLE;

D O I：

10.1016/j.apsb.2013.11.001

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The solid dispersion has become an established solubilization technology for poorly water soluble drugs. Since a solid dispersion is basically a drug-polymer two-component system, the drug-polymer interaction is the determining factor in its design and performance. In this review, we summarize our current understanding of solid dispersions both in the solid state and in dissolution, emphasizing the fundamental aspects of this important technology. (C) 2014 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V.

引用

页码：18 / 25

页数：8

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