Overall assessment of tumor-infiltrating lymphocytes in head and neck squamous cell carcinoma: time to take notice

被引：28

作者：

Almangush, Alhadi ^{[1
,2
,3
,4
]}

Leivo, Ilmo ^{[3
]}

Makitie, Antti A. ^{[2
,5
,6
,7
]}

机构：

[1] Univ Helsinki, Dept Pathol, Helsinki, Finland

[2] Univ Helsinki, Fac Med, Res Program Syst Oncol, Helsinki, Finland

[3] Univ Turku, Inst Biomed, Pathol, Turku, Finland

[4] Univ Misurata, Fac Dent, Misurata, Libya

[5] Univ Helsinki & Hosp, Dept Otorhinolaryngol Head & Neck Surg, Helsinki, Finland

[6] Karolinska Inst, Dept Clin Sci Intervent & Technol, Div Ear Nose & Throat Dis, Stockholm, Sweden

[7] Karolinska Hosp, Stockholm, Sweden

来源：

ACTA OTO-LARYNGOLOGICA | 2020年 / 140卷 / 03期

关键词：

Tumor-infiltrating lymphocytes (TILs); Head and neck squamous cell carcinoma (HNSCC); clinical behavior; PROGNOSTIC VALUE;

D O I：

10.1080/00016489.2020.1720284

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

Background: The immune response has an important role in cancer progression. At the same time, anti-tumor effect of the immune response has been speculated to cause destruction of cancer cells. Recent studies have highlighted the significance of tumor-infiltrating lymphocytes (TILs) in different cancers. The International Immuno-Oncology Biomarkers Working Group has in 2017 published a practical review proposing a standardized method to assess TILs in the routine hematoxylin and eosin (HE) stained sections. Aims/objectives: To discuss the association between TILs and survival in head and neck squamous cell carcinoma (HNSCC). Material and methods: We review recent studies having assessed TILs in HNSCC and showing that tumors having low TILs associate significantly with worse survival. Results: These findings underline that HNSCC cases with low TILs might benefit from multimodality treatment and might be indicated to receive immunotherapy. Conclusions: The evaluation of TILs using routine HE-stained sections is practical and can be considered in assessment of antitumor activity.

引用

页码：246 / 248

页数：3

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