Tumorigenic and Metastatic Activity of Human Thyroid Cancer Stem Cells

被引：186

作者：

Todaro, Matilde ^{[1
]}

Iovino, Flora ^{[1
]}

Eterno, Vincenzo ^{[1
,3
]}

Cammareri, Patrizia ^{[1
,3
]}

Gambara, Guido ^{[4
,5
]}

Espina, Virginia ^{[4
]}

Gulotta, Gaspare ^{[2
]}

Dieli, Francesco

Giordano, Silvia ^{[6
]}

De Maria, Ruggero ^{[5
,7
]}

Stassi, Giorgio ^{[1
,3
]}

机构：

[1] Univ Palermo, Dept Surg & Oncol Sci, Cellular & Mol Pathophysiol Lab, Palermo, Italy

[2] Univ Palermo, Dept GENURTO, Palermo, Italy

[3] IRCCS Fdn Salvatore Maugeri, Pavia, Italy

[4] George Mason Univ, Ctr Appl Prote & Mol Med, Manassas, VA USA

[5] Ist Super Sanita, Dept Hematol & Oncol, I-00161 Rome, Italy

[6] Univ Turin, Sch Med, Inst Canc Res & Treatment, Turin, Italy

[7] Mediterranean Inst Oncol, Catania, Italy

来源：

CANCER RESEARCH | 2010年 / 70卷 / 21期

关键词：

EPITHELIAL-MESENCHYMAL TRANSITION; ALDEHYDE DEHYDROGENASE-ACTIVITY; ACUTE MYELOID-LEUKEMIA; RADIOACTIVE IODINE; TYROSINE KINASE; LUNG-CANCER; CARCINOMA; RECEPTOR; GROWTH; DIFFERENTIATION;

D O I：

10.1158/0008-5472.CAN-10-1994

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Thyroid carcinoma is the most common endocrine malignancy and the first cause of death among endocrine cancers. We show that the tumorigenic capacity in thyroid cancer is confined in a small subpopulation of stem-like cells with high aldehyde dehydrogenase (ALDH(high)) activity and unlimited replication potential. ALDH(high) cells can be expanded indefinitely in vitro as tumor spheres, which retain the tumorigenic potential upon delivery in immunocompromised mice. Orthotopic injection of minute numbers of thyroid cancer stem cells recapitulates the behavior of the parental tumor, including the aggressive metastatic features of undifferentiated thyroid carcinomas, which are sustained by constitutive activation of cMet and Akt in thyroid cancer stem cells. The identification of tumorigenic and metastagenic thyroid cancer cells may provide unprecedented preclinical tools for development and preclinical validation of novel targeted therapies. Cancer Res; 70(21); 8874-85. (C) 2010 AACR.

引用

页码：8874 / 8885

页数：12

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