[6]-Gingerol induces Caspase-Dependent Apoptosis in Bladder Cancer cells via MAPK and ROS Signaling

被引：11

作者：

Choi, Na Ri ^{[1
]}

Choi, Woo-gyun ^{[1
]}

Kwon, Min Ji ^{[1
]}

Woo, Joo Han ^{[2
,3
]}

Kim, Byung Joo ^{[1
]}

机构：

[1] Pusan Natl Univ, Div Longev & Biofunct Med, Sch Korean Med, 49 Busandaehakro, Yangsan 50612, South Korea

[2] Dongguk Univ, Dept Physiol, Coll Med, Gyeongju 38066, South Korea

[3] Dongguk Univ, Coll Med, Channelopathy Res Ctr CRC, 32 Dongguk Ro, Goyang 10326, Gyeonggi Do, South Korea

来源：

INTERNATIONAL JOURNAL OF MEDICAL SCIENCES | 2022年 / 19卷 / 07期

基金：

新加坡国家研究基金会;

关键词：

6]-gingerol; cell proliferation; apoptosis; bladder cancer; 5637; POTENTIAL MELASTATIN 7; TRP CHANNELS; TUMOR-GROWTH; MIGRATION; INHIBITION; GINGER; PROLIFERATION; INVASION; PATHWAYS; DEATH;

D O I：

10.7150/ijms.73077

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The anti-cancer effects of [6]-gingerol ([6]-GIN), the main active polyphenol of ginger (Zingiber officinale), were investigated in the human bladder cancer cell line 5637. [6]-GIN inhibited cell proliferation, increased sub-G1 phase ratios, and depolarized mitochondrial membrane potential. [6]-GIN-induced cell death was associated with the downregulation of B-cell lymphoma 2 (BCL-2) and survivin and the upregulation of Bcl-2-associated X protein (Bax). [6]-GIN activated caspase-3 and caspase-9 and regulated the activation of mitogen-activated protein kinases (MAPKs). Further, [6]-GIN also increased the intracellular reactive oxygen species (ROS) levels and TG100-115 or tranilast increased [6]-GIN-induced cell death. These results suggest that [6]-GIN induced apoptosis in the bladder cancer cell line 5637 and therefore has the potential to be used in the development of new drugs for bladder cancer treatment.

引用

页码：1093 / 1102

页数：10

共 67 条

[61] Aberrant over-expression of TRPM7 ion channels in pancreatic cancer: required for cancer cell invasion and implicated in tumor growth and metastasis [J].