Effects of soy isoflavone extract supplements on blood pressure in adult humans: systematic review and meta-analysis of randomized placebo-controlled trials

被引：67

作者：

Taku, Kyoko ^{[1
]}

Lin, Ning ^{[1
,2
]}

Cai, Donglian ^{[2
]}

Hu, Jianwei ^{[3
]}

Zhao, Xiaohui ^{[3
]}

Zhang, Yumei ^{[3
]}

Wang, Peiyu ^{[4
]}

Melby, Melissa K. ^{[5
]}

Hooper, Lee ^{[6
]}

Kurzer, Mindy S. ^{[7
]}

Mizuno, Shoichi ^{[8
]}

Ishimi, Yoshiko ^{[9
]}

Watanabe, Shaw ^{[5
]}

机构：

[1] Natl Inst Hlth & Nutr, Informat Ctr, Shinjuku Ku, Tokyo 1628636, Japan

[2] Second Mil Med Univ, Changhai Hosp, Dept Clin Nutr, Shanghai, Peoples R China

[3] Peking Univ, Sch Publ Hlth, Dept Food Hyg & Nutr, Beijing, Peoples R China

[4] Peking Univ, Sch Publ Hlth, Dept Social Med & Hlth Educ, Beijing, Peoples R China

[5] Natl Inst Hlth & Nutr, Nutr Educ Program, Tokyo 1628636, Japan

[6] Univ E Anglia, Sch Med Hlth Policy & Practice, Norwich NR4 7TJ, Norfolk, England

[7] Univ Minnesota, Dept Food Sci & Nutr, Minneapolis, MN 55455 USA

[8] Natl Inst Hlth & Nutr, Ctr Collaborat & Partnership, Tokyo 1628636, Japan

[9] Natl Inst Hlth & Nutr, Food Funct & Labeling Program, Tokyo 1628636, Japan

来源：

JOURNAL OF HYPERTENSION | 2010年 / 28卷 / 10期

关键词：

blood pressure; human; hypertension; meta-analysis; soy isoflavone supplements; systematic review; ESTROGEN-RECEPTOR-ALPHA; ENDOTHELIAL FUNCTION; NITRIC-OXIDE; PHYTOESTROGEN GENISTEIN; CARDIOVASCULAR RISK; LDL CHOLESTEROL; JAPANESE WOMEN; PLASMA; RALOXIFENE; FLAVONOIDS;

D O I：

10.1097/HJH.0b013e32833c6edb

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

Objective Reported effects of different soy products on blood pressure vary. This systematic review and meta-analysis was performed to clarify the effects of soy isoflavone extract supplements on systolic and diastolic blood pressure (SBP and DBP) in adult humans. Methods PubMed, CENTRAL, ICHUSHI, and CNKI were searched in June 2009 for relevant randomized placebo-controlled trials. Study data and indicators of methodological validity were independently extracted by two authors using predefined data fields. Meta-analysis was carried out in Review Manager 5.0.22. Results Searches identified 3740 articles, of which 14 randomized controlled trials (789 participants) were included. Daily ingestion of 25-375mg soy isoflavones (aglycone equivalents) for 2-24 weeks significantly decreased SBP by 1.92 mmHg (95% confidence interval -3.45 to -0.39; P=0.01) compared with placebo (heterogeneity P=0.39, fixed effect model) in adults with normal blood pressure and prehypertension. The effect wa

引用

页码：1971 / 1982

页数：12

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