Peptide TQS169 prevents osteoporosis in rats by enhancing osteogenic differentiation and calcium absorption

被引：18

作者：

Wang, Huan ^{[1
]}

Chen, Nanye ^{[1
]}

Shen, Shuru ^{[1
]}

Li, Huiyu ^{[1
]}

Hu, Xiangxiang ^{[1
]}

Yang, Yunkai ^{[1
]}

Yu, Xiaochen ^{[1
]}

Ye, Li ^{[1
]}

Zhou, Wei ^{[2
]}

Feng, Meiqing ^{[1
]}

机构：

[1] Fudan Univ, Sch Pharm, Dept Microbiol & Biochem Pharm, Shanghai 201203, Peoples R China

[2] Fudan Univ, Dept Chem, Shanghai 200433, Peoples R China

来源：

JOURNAL OF FUNCTIONAL FOODS | 2018年 / 49卷

关键词：

Low-calcium diet; MC3T3-E1; cell; Ossotide; Osteogenic differentiation; Osteoporosis; MARROW STROMAL CELLS; GENE-EXPRESSION; POSTMENOPAUSAL WOMEN; HUMAN OSTEOBLASTS; RETINOIC ACID; BONE LOSS; PROLIFERATION; DEFICIENCY; GROWTH; MODEL;

D O I：

10.1016/j.jff.2018.08.021

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

The preventive effects of TQS169 peptide on osteoporosis were investigated and the mechanisms of promoting osteogenic differentiation and calcium absorption were also studied in vitro and vivo in this research. Wistar rats were given a low-Calcium diet treated with different doses of peptide TQS169 and extra CaCl2 for 4 weeks. The content of Calcium, OPG in serum and the Ca content of the femur were increased in high-dose-treated rats. The osteoporosis model induced by retinoic acid was established to measure the related factors. High dosage of TQS169 treated group showed the protective effects. Osteoblastogenesis differentiation of MC3T3-E1 cells treated with TQS169 were accelerated through improving ALP activity, promoting mineral matrix formation and the expression of typical genes of RUNX2, OCN and COL I. Taking all the experiments together, our study confirms the protective effects of TQS169 on osteoporosis and explains the potential mechanism for the first time.

引用

页码：113 / 121

页数：9

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