How the ear's works work: mechanoelectrical transduction and amplification by hair cells

The sensitivity of our hearing is enhanced by an active process that both amplifies and tunes the movements of the ear's sensory receptors, the hair cells. In a quiet environment, the active process can even evoke spontaneous emission of sounds from an ear. Recent research indicates that, at least in non-mammalian tetrapods, the active process results from the interaction of negative stiffness in the mechanosensitive hair bundles with two motor processes, one due to myosin-based adaptation and the other to Ca2+-dependent reclosure of transduction channels. These three processes together explain many of the complex phenomena characteristic of the hearing process. (C) 2005 Academie des sciences. Published by Elsevier SAS. All rights reserved.