An update on the genetics of Gilles de la Tourette syndrome

被引：73
作者：
Pauls, DL [1 ]
机构：
[1] Harvard Univ, Sch Med, Massachusetts Gen Hosp, Psychiat & Neurodev Genet Unit, Charlestown, MA 02129 USA
来源：
JOURNAL OF PSYCHOSOMATIC RESEARCH | 2003年 / 55卷 / 01期
关键词：
Gilles de la Tourette syndrome; family studies; candidate gene studies; genetic linkage studies; AUTOSOMAL-DOMINANT TRANSMISSION; OBSESSIVE-COMPULSIVE DISORDER; ATTENTION-DEFICIT DISORDER; RECEPTOR GENE; LINKAGE DISEQUILIBRIUM; D2-DOPAMINE RECEPTOR; SEGREGATION ANALYSIS; TRANSPORTER GENE; TIC DISORDERS; NO EVIDENCE;
D O I：
10.1016/S0022-3999(02)00586-X
中图分类号：
R749 [精神病学];
学科分类号：
100205 ;
摘要：
Objectives: To summarize the current data suggesting that Gilles de la Tourette syndrome (GTS) is inherited and genetic. Methods: The extant literature on family studies, segregation analyses, candidate genes studies and linkage studies of GTS was reviewed and summarized. Results and conclusions: There is considerable data that suggests that: (1) genetic factors play an important role in the manifestation of GTS; (2) several genes are important with some possibly having major effect; and (3) several regions of the genome have been identified as potential locations of these susceptibility genes. (C) 2003 Elsevier Inc. All rights reserved.
引用
收藏
页码：7 / 12
页数：6
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