An update on the genetics of Gilles de la Tourette syndrome

被引：73

作者：

Pauls, DL ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Massachusetts Gen Hosp, Psychiat & Neurodev Genet Unit, Charlestown, MA 02129 USA

来源：

JOURNAL OF PSYCHOSOMATIC RESEARCH | 2003年 / 55卷 / 01期

关键词：

Gilles de la Tourette syndrome; family studies; candidate gene studies; genetic linkage studies; AUTOSOMAL-DOMINANT TRANSMISSION; OBSESSIVE-COMPULSIVE DISORDER; ATTENTION-DEFICIT DISORDER; RECEPTOR GENE; LINKAGE DISEQUILIBRIUM; D2-DOPAMINE RECEPTOR; SEGREGATION ANALYSIS; TRANSPORTER GENE; TIC DISORDERS; NO EVIDENCE;

D O I：

10.1016/S0022-3999(02)00586-X

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Objectives: To summarize the current data suggesting that Gilles de la Tourette syndrome (GTS) is inherited and genetic. Methods: The extant literature on family studies, segregation analyses, candidate genes studies and linkage studies of GTS was reviewed and summarized. Results and conclusions: There is considerable data that suggests that: (1) genetic factors play an important role in the manifestation of GTS; (2) several genes are important with some possibly having major effect; and (3) several regions of the genome have been identified as potential locations of these susceptibility genes. (C) 2003 Elsevier Inc. All rights reserved.

引用

页码：7 / 12

页数：6

共 69 条

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[22] EVIDENCE FOR AUTOSOMAL-DOMINANT TRANSMISSION IN TOURETTES-SYNDROME - UNITED-KINGDOM COHORT STUDY [J].