An update on the genetics of Gilles de la Tourette syndrome

被引：73
作者：
Pauls, DL [1 ]
机构：
[1] Harvard Univ, Sch Med, Massachusetts Gen Hosp, Psychiat & Neurodev Genet Unit, Charlestown, MA 02129 USA
来源：
JOURNAL OF PSYCHOSOMATIC RESEARCH | 2003年 / 55卷 / 01期
关键词：
Gilles de la Tourette syndrome; family studies; candidate gene studies; genetic linkage studies; AUTOSOMAL-DOMINANT TRANSMISSION; OBSESSIVE-COMPULSIVE DISORDER; ATTENTION-DEFICIT DISORDER; RECEPTOR GENE; LINKAGE DISEQUILIBRIUM; D2-DOPAMINE RECEPTOR; SEGREGATION ANALYSIS; TRANSPORTER GENE; TIC DISORDERS; NO EVIDENCE;
D O I：
10.1016/S0022-3999(02)00586-X
中图分类号：
R749 [精神病学];
学科分类号：
100205 ;
摘要：
Objectives: To summarize the current data suggesting that Gilles de la Tourette syndrome (GTS) is inherited and genetic. Methods: The extant literature on family studies, segregation analyses, candidate genes studies and linkage studies of GTS was reviewed and summarized. Results and conclusions: There is considerable data that suggests that: (1) genetic factors play an important role in the manifestation of GTS; (2) several genes are important with some possibly having major effect; and (3) several regions of the genome have been identified as potential locations of these susceptibility genes. (C) 2003 Elsevier Inc. All rights reserved.
引用
收藏
页码：7 / 12
页数：6
相关论文
共 69 条
  • [1] A factor analysis of tic symptoms in Gilles de la Tourette's syndrome
    Alsobrook, JP
    Pauls, DL
    [J]. AMERICAN JOURNAL OF PSYCHIATRY, 2002, 159 (02) : 291 - 296
  • [2] Barr CL, 1999, AM J MED GENET, V88, P437, DOI 10.1002/(SICI)1096-8628(19990820)88:4<437::AID-AJMG24>3.0.CO
  • [3] 2-E
  • [4] Catechol-O-methyltransferase and Gilles de la Tourette syndrome
    Barr, CL
    Wigg, KG
    Sandor, P
    [J]. MOLECULAR PSYCHIATRY, 1999, 4 (05) : 492 - 495
  • [5] Barr CL, 1996, AM J MED GENET, V67, P301, DOI 10.1002/(SICI)1096-8628(19960531)67:3<301::AID-AJMG6>3.0.CO
  • [6] 2-P
  • [7] Barr CL, 1997, AM J MED GENET, V74, P58, DOI 10.1002/(SICI)1096-8628(19970221)74:1<58::AID-AJMG13>3.0.CO
  • [8] 2-Q
  • [9] Neuroreceptor subunit genes and the genetic susceptibility to Gilles de la Tourette syndrome
    Brett, PM
    Curtis, D
    Robertson, MM
    Gurling, HMD
    [J]. BIOLOGICAL PSYCHIATRY, 1997, 42 (10) : 941 - 947
  • [10] BRETT PM, 1995, AM J PSYCHIAT, V152, P437
1234567