Transfusion-related acute lung injury following intravenous anti-D administration in an adolescent

被引：16

作者：

Berger-Achituv, Sivan ^{[1
]}

Ellis, Martin H. ^{[2
,3
]}

Curtis, Brian R. ^{[4
]}

Wolach, Baruch ^{[1
,3
]}

机构：

[1] Meir Med Ctr, Dept Pediat, Kefar Sava, Israel

[2] Meir Med Ctr, Kefar Sava, Israel

[3] Tel Aviv Univ, Sackler Fac Med, IL-69978 Tel Aviv, Israel

[4] Blood Ctr Wisconsin, Platelet & Neutrophil Immunol Lab, Milwaukee, WI USA

来源：

AMERICAN JOURNAL OF HEMATOLOGY | 2008年 / 83卷 / 08期

关键词：

D O I：

10.1002/ajh.21185

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Transfusion-related acute lung injury (TRALI) is associated with administration of all plasma containing blood products. We present a 14-year-old adolescent diagnosed with idiopathic thrombocytopenic purpura who developed acute respiratory insufficiency compatible with TRALI within 5 hr following intravenous anti-D. Full blown noncardiogenic pulmonary edema was noted after 9 hr. Mechanical ventilation was not required and the patient made a full recovery after 36 hr. Analysis of the anti-D preparation revealed reactivity against the neutrophil Fc gamma RIIIb. A postinfusion serum sample contained antibodies against class I human HLA-A11 antigen. Clinicians should consider TRALI in patients developing unexplained dyspnea after receiving intravenous anti-D.

引用

页码：676 / 678

页数：3

共 22 条

[11] Neutrophils and their Fcγ receptors are essential in a mouse model of transfusion-related acute lung injury [J].