Non-covalent phosphorylcholine coating reduces protein adsorption and phagocytic uptake of microparticles

被引：7
|
作者：
Garapaty, Anusha [1 ]
Champion, Julie A. [1 ]
机构：
[1] Georgia Inst Technol, Sch Chem & Biomol Engn, Atlanta, GA 30332 USA
来源：
CHEMICAL COMMUNICATIONS | 2015年 / 51卷 / 72期
关键词：
SELF-ASSEMBLED MONOLAYERS; POLYMER NANOPARTICLES; OXIDE NANOPARTICLES; STRONG RESISTANCE; SURFACE-CHARGE; SERUM-PROTEINS; CELLS; PEG; ACTIVATION; ADHESION;
D O I：
10.1039/c5cc03459k
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Phosphorylcholine co-polymer was assembled on model polystyrene microparticles through a simple, widely-applicable ethanol coating process. The coating rendered particles resistant to protein adsorption and phagocytosis by macrophages, making it useful for a range of biological applications.
引用
收藏
页码：13814 / 13817
页数：4
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