Alsmaphorazines C-E, indole alkaloids from Alstonia pneumatophora

被引：20

作者：

Koyama, Koichiro ^{[1
]}

Hirasawa, Yusuke ^{[1
]}

Nugroho, Alfarius E. ^{[1
]}

Kaneda, Toshio ^{[1
]}

Hoe, Teh Chin ^{[2
]}

Chan, Kit-Lam ^{[2
]}

Morita, Hiroshi ^{[1
]}

机构：

[1] Hoshi Univ, Fac Pharmaceut Sci, Shinagawa Ku, Tokyo 1428501, Japan

[2] Univ Sains Malaysia, Sch Pharmaceut Sci, George Town 11800, Malaysia

来源：

TETRAHEDRON | 2012年 / 68卷 / 05期

关键词：

Indole alkaloids; Alston ia pneumatophora; Alsmaphorazines C-E; Modified Masher's method; MOLECULAR-FORCE FIELD; VAN-DER-WAALS; EXTRACTS; MODEL;

D O I：

10.1016/j.tet.2011.12.014

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Three novel indole alkaloids, alsmaphorazines C (1)-E (3), were isolated from the leaves of Alstonia pneumatophora (Apocynaceae) and their structures were determined on the basis of the 2D NMR and MS spectral analyses. The absolute configurations of 1 and 3 were elucidated by applying a modified Mosher's method and CD spectral analysis. These alkaloids possessed novel ring skeletons containing an octahydropyrrolo[2,3-blpyrrole unit. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：1502 / 1506

页数：5

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