NINTEDANIB IN IDIOPATHIC PULMONARY FIBROSIS

被引：0

作者：

Woodcock, H. V. ^{[1
]}

Maher, T. M. ^{[1
,2
,3
]}

机构：

[1] UCL, Ctr Injury & Tissue Repair, London WC1E 6BT, England

[2] Royal Brompton Hosp, NIHR Resp Biomed Res Unit, London, England

[3] Univ London Imperial Coll Sci Technol & Med, Natl Heart & Lung Inst, Fibrosis Res Grp, London SW7, England

来源：

DRUGS OF TODAY | 2015年 / 51卷 / 06期

关键词：

Usual interstitial pneumonia; Therapeutics; Clinical trials; Acute exacerbations; FIBROBLAST-GROWTH-FACTOR; TRIPLE ANGIOKINASE INHIBITOR; TYROSINE KINASE INHIBITOR; INDUCED LUNG FIBROSIS; BIBF; 1120; PHASE-I; TRANSFORMING GROWTH-FACTOR-BETA-1; BRONCHOALVEOLAR LAVAGE; GENE-EXPRESSION; ANIMAL-MODELS;

D O I：

10.1358/dot.2015.051.06.2336331

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Idiopathic pulmonary fibrosis (IPF) conveys a median survival of 3 years and until recently has lacked effective therapies. Nintedanib, an orally available, small-molecule tyrosine kinase inhibitor with selectivity for vascular endothelial growth factor (VEGF), platelet-derived growth factor (PDGF) and fibroblast growth factor (FGF) receptors has recently been shown, in two pivotal phase III studies, to effectively slow IPF disease progression. Consequently, nintedanib was given accelerated approval by the FDA in October 2014 for the treatment of IPF. This monograph explores the preclinical rationale for the antifibrotic role of nintedanib and provides an overview of the available data on pharmacokinetics, efficacy and safety.

引用

页码：345 / 356

页数：12

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