Designed synthesis of uniformly sized iron oxide nanoparticles for efficient magnetic resonance imaging contrast agents

被引：822

作者：

Lee, Nohyun

Hyeon, Taeghwan ^{[1
,2
]}

机构：

[1] Seoul Natl Univ, World Class Univ Program Chem Convergence Energy, Seoul 151744, South Korea

[2] Seoul Natl Univ, Sch Chem & Biol Engn, Seoul 151744, South Korea

来源：

CHEMICAL SOCIETY REVIEWS | 2012年 / 41卷 / 07期

基金：

新加坡国家研究基金会;

关键词：

CORE-SHELL NANOPARTICLES; CHEMICAL-EXCHANGE MODEL; MRI CONTRAST; BIOLOGICAL APPLICATIONS; BIOMEDICAL APPLICATIONS; NANOCRYSTALS; RELAXIVITY; DELIVERY; SPHERES; CELLS;

D O I：

10.1039/c1cs15248c

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Various magnetic nanoparticles have been extensively investigated as novel magnetic resonance imaging (MRI) contrast agents owing to their unique characteristics, including efficient contrast effects, biocompatibility, and versatile surface functionalization capability. Nanoparticles with high relaxivity are very desirable because they would increase the accuracy of MRI. Recent progress in nanotechnology enables fine control of the size, crystal structure, and surface properties of iron oxide nanoparticles. In this tutorial review, we discuss how MRI contrast effects can be improved by controlling the size, composition, doping, assembly, and surface properties of iron-oxide-based nanoparticles.

引用

页码：2575 / 2589

页数：15

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