Electrochemical study of the effect of functionalized nickel nanoparticles on cellular uptake of leukemia cancer cells in vitro

被引：6

作者：

Guo, Da Dong ^{[1
]}

Wu, Chun Hui ^{[1
]}

Wang, Xue Mei ^{[1
]}

Chen, Bao An ^{[2
]}

机构：

[1] SE Univ, Chien Shiung Wu Lab, State Key Lab Bioelect, Nanjing 210096, Peoples R China

[2] SE Univ, Zhongda Hosp, Sch Clin Med, Nanjing 210096, Peoples R China

来源：

CHINESE CHEMICAL LETTERS | 2008年 / 19卷 / 05期

基金：

中国国家自然科学基金;

关键词：

nickel nanoparticles; leukemia cancer cells; quercetin; electrochemical assay;

D O I：

10.1016/j.cclet.2008.01.038

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In this study, we have fabricated the functionalized nickel nanoparticles and investigated their effects on cellular uptake of quercetin in leukemia K562 cancer cells by using electrochemical assay. The results indicate that nickel nanoparticles could efficiently enhance the quercetin uptake and increase the intracellular accumulation in cancer cells, implying the great potential of functionalized nickel nanoparticles in target cancer therapy. (C) 2008 Xue Mei Wang. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.

引用

页码：577 / 580

页数：4

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