Recent advances in the therapeutic potential of emodin for human health

被引：62

作者：

Sharifi-Rad, Javad ^{[1
]}

Herrera-Bravo, Jesus ^{[2
,3
]}

Kamiloglu, Senem ^{[4
,5
]}

Petroni, Katia ^{[6
]}

Mishra, Abhay Prakash ^{[7
]}

Monserrat-Mesquida, Margalida ^{[8
,9
,10
]}

Sureda, Antoni ^{[8
,9
,10
]}

Martorell, Miquel ^{[2
,11
,12
]}

Aidarbekovna, Dossymbetova Symbat ^{[13
]}

Yessimsiitova, Zura ^{[14
]}

Ydyrys, Alibek ^{[15
]}

Hano, Christophe ^{[16
]}

Calina, Daniela ^{[17
]}

Cho, William C. ^{[18
]}

机构：

[1] Univ Azuay, Fac Med, Cuenca, Ecuador

[2] Univ Santo Tomas, Dept Ciencias Basicas, Fac Ciencias, Santiago, Chile

[3] Univ La Frontera, Ctr Mol Biol & Pharmacogenet Sci & Technol Biores, Temuco 4811230, Chile

[4] Bursa Uludag Univ, Fac Agr, Dept Food Engn, TR-16059 Bursa, Turkey

[5] Bursa Uludag Univ, Sci & Technol Applicat & Res Ctr BITUAM, TR-16059 Bursa, Turkey

[6] Univ Milan, Dipartimento Biosci, Via Celoria 26, I-20133 Milan, Italy

[7] HNB Garhwal Cent Univ, Dept Pharmaceut Chem, Srinagar 246174, Uttarakhand, India

[8] Univ Balearic Isl IUNICS, Univ Res Inst Hlth, Res Grp Community Nutr & Oxidat Stress, Palma De Mallorca 07122, Spain

[9] Univ Balearic Isl IUNICS, Hlth Res Inst Balearic Isl IdISBa, Palma De Mallorca 07122, Spain

[10] Inst Salud Carlos III ISCIII, CIBER Physiopathol Obes & Nutr CIBEROBN, Madrid 28029, Spain

[11] Univ Concepcion, Fac Pharm, Dept Nutr & Dietet, Concepcion 4070386, Chile

[12] Univ Concepcion, Ctr Hlth Living, Concepcion 4070386, Chile

[13] Kazakh Russian Med Univ, Almaty Tecnol Univ, Str Tole Bi 100,Str Torekulova 71, Alma Ata 050012, Kazakhstan

[14] Al Farabi Kazakh Natl Univ, Dept Biodivers & Bioresource, Al Farabi Av 71, Alma Ata 050040, Kazakhstan

[15] Al Farabi Kazakh Natl Univ, Biomed Res Ctr, Al Farabi Av 71, Alma Ata 050040, Kazakhstan

[16] Univ Orleans, Dept Biol Chem, Eure & Loir Campus, F-28000 Chartres, Eure & Loir, France

[17] Univ Med & Pharm Craiova, Dept Clin Pharm, Craiova 200349, Romania

[18] Queen Elizabeth Hosp, Dept Clin Oncol, Kowloon, Hong Kong, Peoples R China

来源：

BIOMEDICINE & PHARMACOTHERAPY | 2022年 / 154卷

关键词：

Emodin; Pharmacological properties; Molecular mechanisms; Signaling pathways; Clinical trials; POLYGONI MULTIFLORI RADIX; SEVERE ACUTE-PANCREATITIS; OXIDATIVE STRESS; ALOE-EMODIN; IN-VITRO; UDP-GLUCURONOSYLTRANSFERASES; ANTHRAQUINONES EMODIN; TISSUE DISTRIBUTION; DOWN-REGULATION; CANCER CELLS;

D O I：

10.1016/j.biopha.2022.113555

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Emodin (1,3,8-trihydroxy-6-methylanthraquinone) is a bioactive compound, a natural anthraquinone aglycone, present mainly in herbaceous species of the families Fabaceae, Polygonaceae and Rhamnaceae, with a physio-logical role in protection against abiotic stress in vegetative tissues. Emodin is mainly used in traditional Chinese medicine to treat sore throats, carbuncles, sores, blood stasis, and damp-heat jaundice. Pharmacological research in the last decade has revealed other potential therapeutic applications such as anticancer, neuroprotective, antidiabetic, antioxidant and anti-inflammatory.The present study aimed to summarize recent studies on bioavailability, preclinical pharmacological effects with evidence of molecular mechanisms, clinical trials and clinical pitfalls, respectively the therapeutic limita-tions of emodin. For this purpose, extensive searches were performed using the PubMed/Medline, Scopus, Google scholar, TRIP database, Springer link, Wiley and SciFinder databases as a search engines. The in vitro and in vivo studies included in this updated review highlighted the signaling pathways and molecular mechanisms of emodin. Because its bioavailability is low, there are limitations in clinical therapeutic use. In conclusion, for an increase in pharmacotherapeutic efficacy, future studies with carrier molecules to the target, thus opening up new therapeutic perspectives.

引用

页数：17

共 154 条

[61] RETRACTED: Emodin attenuates apoptosis and inflammation induced by LPS through up-regulating lncRNA TUG1 in murine chondrogenic ATDC5 cells (Retracted article. See vol. 153, 2022) [J].