Physiopathology of the cochlear microcirculation

被引：158
作者：
Shi, Xiaorui [1 ]
机构：
[1] Oregon Hlth & Sci Univ, Dept Otolaryngol Head & Neck Surg, Oregon Hearing Res Ctr NRC04, Portland, OR 97239 USA
来源：
HEARING RESEARCH | 2011年 / 282卷 / 1-2期
基金：
美国国家卫生研究院;
关键词：
SPIRAL MODIOLAR ARTERY; SENSORINEURAL HEARING-LOSS; RECEPTORS MEDIATE VASOCONSTRICTION; ASTROCYTE-ENDOTHELIAL INTERACTIONS; BLOOD-LABYRINTH BARRIER; NITRIC-OXIDE PRODUCTION; AGE-RELATED-CHANGES; INNER-EAR; GUINEA-PIG; STRIA VASCULARIS;
D O I：
10.1016/j.heares.2011.08.006
中图分类号：
R36 [病理学]; R76 [耳鼻咽喉科学];
学科分类号：
100104 ; 100213 ;
摘要：
Normal blood supply to the cochlea is critically important for establishing the endocochlear potential and sustaining production of endolymph. Abnormal cochlear microcirculation has long been considered an etiologic factor in noise-induced hearing loss, age-related hearing loss (presbycusis), sudden hearing loss or vestibular function, and Meniere's disease. Knowledge of the mechanisms underlying the pathophysiology of cochlear microcirculation is of fundamental clinical importance. A better understanding of cochlear blood flow (CoBF) will enable more effective management of hearing disorders resulting from aberrant blood flow. This review focuses on recent discoveries and findings related to the physiopathology of the cochlear microvasculature. Published by Elsevier B.V.
引用
收藏
页码：10 / 24
页数：15
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