A study to establish gestation-specific reference intervals for thyroid function tests in normal singleton pregnancy

被引：36

作者：

Cotzias, Christina ^{[1
]}

Wong, Sarah-Jane ^{[2
]}

Taylor, Erica ^{[3
]}

Seed, Paul ^{[4
]}

Girling, Joanna ^{[5
]}

机构：

[1] W Middlesex Univ Hosp, Isleworth TW7 6AF, Middx, England

[2] Brondesbury Med Ctr, London NW6 7JQ, England

[3] Quest Diagnost, Unit B1, Heston TW5, Middx, England

[4] St Guys & St Thomas NHS Fdn Trust, London SE1 7EH, England

[5] W Middlesex Univ Hosp, Isleworth TW9 2AL, Middx, England

来源：

EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY | 2008年 / 137卷 / 01期

关键词：

gestation-specific; thyroid function; free thyroxine; thyroid stimulating hormone; normal interval;

D O I：

10.1016/j.ejogrb.2007.10.007

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Objective: To establish gestation-specific reference intervals for thyroid function tests in normal singleton pregnancy. Study design: Cross-sectional observational study performed in the Obstetric and Gynaecology department, West Middlesex University Hospital. A single blood sample from 335 pregnant women at various gestations of pregnancy was analysed for thyroid function. FT4, fT3, TSH values at each gestation of pregnancy were calculated. Results: From the fT3, fT4 and TSH results, a 95% reference interval was calculated for each hormone for each week of pregnancy. Conclusion: We calculated gestation-specific reference intervals for thyroid function tests throughout pregnancy to facilitate clinical management of thyroid disease in pregnancy. (c) 2007 Elsevier Ireland Ltd. All rights reserved.

引用

页码：61 / 66

页数：6

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