Muscle LIM protein plays both structural and functional roles in skeletal muscle

被引:53
作者
Barash, IA
Mathew, L
Lahey, M
Greaser, ML
Lieber, RL
机构
[1] Vet Adm Med Ctr, Dept Orthopaed, La Jolla, CA 92161 USA
[2] Univ Calif San Diego, Dept Orthopaed, San Diego, CA 92103 USA
[3] Univ Calif San Diego, Dept Bioengn, San Diego, CA 92103 USA
[4] Univ Calif San Diego, Biomed Sci Grad Grp, San Diego, CA 92103 USA
[5] Univ Wisconsin, Muscle Biol Lab, Madison, WI 53706 USA
来源
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY | 2005年 / 289卷 / 05期
关键词
eccentric contractions; passive tension;
D O I
10.1152/ajpcell.00117.2005
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Muscle LIM protein (MLP) has been suggested to be an important mediator of mechanical stress in cardiac tissue, but the role that it plays in skeletal muscle remains unclear. Previous studies have shown that it is dramatically upregulated in fast-to-slow fiber-type transformation and also after eccentric contraction (EC)-induced muscle injury. The functional consequences of this upregulation, if any, are unclear. In the present study, we have examined the skeletal muscle phenotype of MLP-knockout (MLPKO) mice in terms of their response to EC-induced muscle injuries. The data suggest that while the MLPKO mice recover completely after EC-induced injury, their torque production lags behind that of heterozygous littermates in the early stages of the recovery process. This lag is accompanied by decreased expression of the muscle regulatory factor MyoD, suggesting that MLP may influence gene expression. In addition, there is evidence of type I fiber atrophy and a shorter resting sarcomere length in the MLPKO mice, but no significant differences in fiber type distribution. In summary, MLP appears to play a subtle role in the maintenance of normal muscle characteristics and in the early events of the recovery process of skeletal muscle to injury, serving both structural and gene-regulatory roles.
引用
收藏
页码:C1312 / C1320
页数:9
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