Muscle LIM protein plays both structural and functional roles in skeletal muscle

被引:53
作者
Barash, IA
Mathew, L
Lahey, M
Greaser, ML
Lieber, RL
机构
[1] Vet Adm Med Ctr, Dept Orthopaed, La Jolla, CA 92161 USA
[2] Univ Calif San Diego, Dept Orthopaed, San Diego, CA 92103 USA
[3] Univ Calif San Diego, Dept Bioengn, San Diego, CA 92103 USA
[4] Univ Calif San Diego, Biomed Sci Grad Grp, San Diego, CA 92103 USA
[5] Univ Wisconsin, Muscle Biol Lab, Madison, WI 53706 USA
来源
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY | 2005年 / 289卷 / 05期
关键词
eccentric contractions; passive tension;
D O I
10.1152/ajpcell.00117.2005
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Muscle LIM protein (MLP) has been suggested to be an important mediator of mechanical stress in cardiac tissue, but the role that it plays in skeletal muscle remains unclear. Previous studies have shown that it is dramatically upregulated in fast-to-slow fiber-type transformation and also after eccentric contraction (EC)-induced muscle injury. The functional consequences of this upregulation, if any, are unclear. In the present study, we have examined the skeletal muscle phenotype of MLP-knockout (MLPKO) mice in terms of their response to EC-induced muscle injuries. The data suggest that while the MLPKO mice recover completely after EC-induced injury, their torque production lags behind that of heterozygous littermates in the early stages of the recovery process. This lag is accompanied by decreased expression of the muscle regulatory factor MyoD, suggesting that MLP may influence gene expression. In addition, there is evidence of type I fiber atrophy and a shorter resting sarcomere length in the MLPKO mice, but no significant differences in fiber type distribution. In summary, MLP appears to play a subtle role in the maintenance of normal muscle characteristics and in the early events of the recovery process of skeletal muscle to injury, serving both structural and gene-regulatory roles.
引用
收藏
页码:C1312 / C1320
页数:9
相关论文
共 33 条
[1]   MUSCLE LIM PROTEIN, A NOVEL ESSENTIAL REGULATOR OF MYOGENESIS, PROMOTES MYOGENIC DIFFERENTIATION [J].
ARBER, S ;
HALDER, G ;
CARONI, P .
CELL, 1994, 79 (02) :221-231
[2]   MLP-deficient mice exhibit a disruption of cardiac cytoarchitectural organization, dilated cardiomyopathy, and heart failure [J].
Arber, S ;
Hunter, JJ ;
Ross, J ;
Hongo, M ;
Sansig, G ;
Borg, J ;
Perriard, JC ;
Chien, KR ;
Caroni, P .
CELL, 1997, 88 (03) :393-403
[3]   Rapid muscle-specific gene expression changes after a single bout of eccentric contractions in the mouse [J].
Barash, IA ;
Mathew, L ;
Ryan, AF ;
Chen, J ;
Lieber, RL .
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 2004, 286 (02) :C355-C364
[4]   RELATIONSHIP BETWEEN MUSCLE-FIBER TYPES AND SIZES AND MUSCLE ARCHITECTURAL PROPERTIES IN THE MOUSE HINDLIMB [J].
BURKHOLDER, TJ ;
FINGADO, B ;
BARON, S ;
LIEBER, RL .
JOURNAL OF MORPHOLOGY, 1994, 221 (02) :177-190
[5]   Differential global gene expression in red and white skeletal muscle [J].
Campbell, WG ;
Gordon, SE ;
Carlson, CJ ;
Pattison, JS ;
Hamilton, MT ;
Booth, FW .
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 2001, 280 (04) :C763-C768
[6]   Response of rat muscle to acute resistance exercise defined by transcriptional and translational profiling [J].
Chen, YW ;
Nader, GA ;
Baar, KR ;
Fedele, MJ ;
Hoffman, EP ;
Esser, KA .
JOURNAL OF PHYSIOLOGY-LONDON, 2002, 545 (01) :27-41
[7]  
Cooper RN, 1999, J CELL SCI, V112, P2895
[8]   Changes in skeletal muscle biochemistry and histology relative to fiber type in rats with heart failure [J].
Delp, MD ;
Duan, CP ;
Mattson, JP ;
Musch, TI .
JOURNAL OF APPLIED PHYSIOLOGY, 1997, 83 (04) :1291-1299
[9]   CHEMICALLY SKINNED MAMMALIAN SKELETAL-MUSCLE .1. STRUCTURE OF SKINNED RABBIT PSOAS [J].
EASTWOOD, AB ;
WOOD, DS ;
BOCK, KL ;
SORENSON, MM .
TISSUE & CELL, 1979, 11 (03) :553-566
[10]   Downregulation and nuclear relocation of MLP during the progression of right ventricular hypertrophy induced by chronic pressure overload [J].
Ecarnot-Laubriet, A ;
De Luca, K ;
Vandroux, D ;
Moisant, M ;
Bernard, C ;
Assem, M ;
Rochette, L ;
Teyssier, JR .
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2000, 32 (12) :2385-2395