Oncogene-induced senescence and melanoma: where do we stand?

被引：17

作者：

Peeper, Daniel S. ^{[1
]}

机构：

[1] Netherlands Canc Inst, Div Mol Genet, NL-1066 CX Amsterdam, Netherlands

来源：

PIGMENT CELL & MELANOMA RESEARCH | 2011年 / 24卷 / 06期

关键词：

nevus; melanoma; senescence; tumor suppression; DNA-DAMAGE RESPONSE; CELLULAR SENESCENCE; BRAF MUTATIONS; P53; HETEROCHROMATIN; CELLS; IMMORTALIZATION; RESTORATION; SUPPRESSION; P16(INK4A);

D O I：

10.1111/j.1755-148X.2011.00933.x

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In recent years, many groups have detected biomarkers of cellular senescence in a plethora of neoplastic lesions, in model systems, and humans. Indeed, we have come to realize that oncogene-induced senescence (OIS) acts as a potent barrier to oncogenic transformation, operating alongside cell death programs. We have begun to uncover some of its underlying principles, but many fundamental questions remain. In this perspective, some of the knowns and unknowns of OIS are discussed, with a focus on melanomagenesis.

引用

页码：1107 / 1111

页数：5

共 53 条

[21] A BIOMARKER THAT IDENTIFIES SENESCENT HUMAN-CELLS IN CULTURE AND IN AGING SKIN IN-VIVO [J].

DIMRI, GP ;

LEE, XH ;

BASILE, G ;

ACOSTA, M ;

SCOTT, C ;

ROSKELLEY, C ;

MEDRANO, EE ;

LINSKENS, M ;

RUBELJ, I ;

PEREIRASMITH, O ;

PEACOCKE, M ;

CAMPISI, J .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (20) :9363-9367

[22] Advances in melanoma senescence and potential clinical application [J].

Giuliano, Sandy ;

Ohanna, Mickael ;

Ballotti, Robert ;

Bertolotto, Corine .

PIGMENT CELL & MELANOMA RESEARCH, 2011, 24 (02) :295-308

[23] Melanocytic nevus-like hyperplasia and melanoma in transgenic BRAFV600E mice [J].

Goel, V. K. ;

Ibrahim, N. ;

Jiang, G. ;

Singhal, M. ;

Fee, S. ;

Flotte, T. ;

Westmoreland, S. ;

Haluska, F. S. ;

Hinds, P. W. ;

Haluska, F. G. .

ONCOGENE, 2009, 28 (23) :2289-2298

[24] Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions [J].

Gorgoulis, VG ;

Vassiliou, LVF ;

Karakaidos, P ;

Zacharatos, P ;

Kotsinas, A ;

Liloglou, T ;

Venere, M ;

DiTullio, RA ;

Kastrinakis, NG ;

Levy, B ;

Kletsas, D ;

Yoneta, A ;

Herlyn, M ;

Kittas, C ;

Halazonetis, TD .

NATURE, 2005, 434 (7035) :907-913

[25] Cellular senescence in naevi and immortalisation in melanoma: a role for p16? [J].

Gray-Schopfer, V. C. ;

Cheong, S. C. ;

Chong, H. ;

Chow, J. ;

Moss, T. ;

Abdel-Malek, Z. A. ;

Marais, R. ;

Wynford-Thomas, D. ;

Bennett, D. C. .

BRITISH JOURNAL OF CANCER, 2006, 95 (04) :496-505

[26] HOMOZYGOTES FOR CDKN2 (P16) GERMLINE MUTATION IN DUTCH FAMILIAL MELANOMA KINDREDS [J].

GRUIS, NA ;

VANDERVELDEN, PA ;

SANDKUIJL, LA ;

PRINS, DE ;

WEAVERFELDHAUS, J ;

KAMB, A ;

BERGMAN, W ;

FRANTS, RR .

NATURE GENETICS, 1995, 10 (03) :351-353

[27] Oncogene-Induced Senescence Does Not Require the p16INK4a or p14ARF Melanoma Tumor Suppressors [J].

Haferkamp, Sebastian ;

Scurr, Lyndee L. ;

Becker, Therese M. ;

Frausto, Monika ;

Kefford, Richard F. ;

Rizos, Helen .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2009, 129 (08) :1983-1991

[28] Cellular senescence in aging primates [J].

Herbig, U ;

Ferreira, M ;

Condel, L ;

Carey, D ;

Sedivy, JM .

SCIENCE, 2006, 311 (5765) :1257-1257

[29] Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice [J].

Jaskelioff, Mariela ;

Muller, Florian L. ;

Paik, Ji-Hye ;

Thomas, Emily ;

Jiang, Shan ;

Adams, Andrew C. ;

Sahin, Ergun ;

Kost-Alimova, Maria ;

Protopopov, Alexei ;

Cadinanos, Juan ;

Horner, James W. ;

Maratos-Flier, Eleftheria ;

DePinho, Ronald A. .

NATURE, 2011, 469 (7328) :102-U1700

[30] In Vivo Identification of Tumor-Suppressive PTEN ceRNAs in an Oncogenic BRAF-Induced Mouse Model of Melanoma [J].

Karreth, Florian A. ;

Tay, Yvonne ;

Perna, Daniele ;

Ala, Ugo ;

Tan, Shen Mynn ;

Rust, Alistair G. ;

DeNicola, Gina ;

Webster, Kaitlyn A. ;

Weiss, Dror ;

Perez-Mancera, Pedro A. ;

Krauthammer, Michael ;

Halaban, Ruth ;

Provero, Paolo ;

Adams, David J. ;

Tuveson, David A. ;

Pandolfi, Pier Paolo .

CELL, 2011, 147 (02) :382-395

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