Oncogene-induced senescence and melanoma: where do we stand?

被引：17

作者：

Peeper, Daniel S. ^{[1
]}

机构：

[1] Netherlands Canc Inst, Div Mol Genet, NL-1066 CX Amsterdam, Netherlands

来源：

PIGMENT CELL & MELANOMA RESEARCH | 2011年 / 24卷 / 06期

关键词：

nevus; melanoma; senescence; tumor suppression; DNA-DAMAGE RESPONSE; CELLULAR SENESCENCE; BRAF MUTATIONS; P53; HETEROCHROMATIN; CELLS; IMMORTALIZATION; RESTORATION; SUPPRESSION; P16(INK4A);

D O I：

10.1111/j.1755-148X.2011.00933.x

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In recent years, many groups have detected biomarkers of cellular senescence in a plethora of neoplastic lesions, in model systems, and humans. Indeed, we have come to realize that oncogene-induced senescence (OIS) acts as a potent barrier to oncogenic transformation, operating alongside cell death programs. We have begun to uncover some of its underlying principles, but many fundamental questions remain. In this perspective, some of the knowns and unknowns of OIS are discussed, with a focus on melanomagenesis.

引用

页码：1107 / 1111

页数：5

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