A novel drug delivery system obtained from hydrophobic modified amphiphilic polymers by Maillard reaction

In order to improve the bioavailability of paditaxel, hemicellulose fractions from hot water pretreatment liquor were the first time to design new amphiphilic polymers through the Maillard reaction. Structural characteristics, emulsifying and drug release behaviors of the amphiphilic polymers were then investigated in detail. Results showed that the amphiphilic polymers with degrees of substitution ranging from 0.31 to 1.65 were obtained by reacting hemicellulose fractions with dodecylamine. Furthermore, the nanometer paclitaxel emusion was successfully preparaed. The amphiphilic polymer provided excellent emulsifying properties and desired storage stability. The average particle sizes of emulsion stayed in the range of 235-266 nm, even after 90 days of storage. Besides, the amphiphilic polymer also proved considerable paclitaxel preservation ability and released performance of pH-responsive. The controlled release of paclitaxel was better at pH 5.0, and thus the new amphiphilic polymer can be used as a delivery carrier of hydrophobic drugs. (C) 2018 Elsevier B.V. All rights reserved.