The road to effective and accessible antibody therapies against Ebola virus

被引：14

作者：

Fausther-Bovendo, Hugues ^{[1
]}

Kobinger, Gary ^{[2
]}

机构：

[1] Global Urgent & Adv Res & Dev, Batiscan, PQ, Canada

[2] Univ Texas Med Branch, Galveston Natl Lab, Galveston, TX 77555 USA

来源：

CURRENT OPINION IN VIROLOGY | 2022年 / 54卷

关键词：

MONOCLONAL-ANTIBODIES; PAN-EBOLAVIRUS; HEMORRHAGIC-FEVER; GENE-TRANSFER; DISEASE; PROTECTION; INFECTION; COCKTAIL; THERAPEUTICS; PERSISTENCE;

D O I：

10.1016/j.coviro.2022.101210

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Ebola virus (EBOV) outbreaks can claim thousands of lives, cripple healthcare systems and local economies. Effective vaccines and treatments against EBOV are therefore needed to limit the impact of this deadly disease. In 2019, a hallmark clinical trial demonstrated the efficacy of monoclonal antibody (mAb) against EBOV. Despite, this recent success, survival of individuals with high viremia remains low. Effective immunotherapies against other Ebolavirus species are still under pre-clinical development. More importantly, the cost of immunotherapies is prohibitive to most individual and affected countries. Novel manufacturing and administration strategies of mAb protein or genetic information could substantially reduce the cost of immunotherapies; hence making them valuable tools against EBOV and other infectious agents.

引用

页数：6

共 49 条

[1] An oral administration of a recombinant anti-TNF fusion protein is biologically active in the gut promoting regulatory T cells: Results of a phase I clinical trial using a novel oral anti-TNF alpha-based therapy [J].

Almon, Einat ;

Khoury, Tawfik ;

Drori, Ariel ;

Gingis-Velitski, Svetlana ;

Alon, Sari ;

Chertkoff, Raul ;

Mushkat, Mordechai ;

Shaaltiel, Yoseph ;

Ilan, Yaron .

JOURNAL OF IMMUNOLOGICAL METHODS, 2017, 446 :21-29

[2] In Vivo Production of Monoclonal Antibodies by Gene Transfer via Electroporation Protects against Lethal Influenza and Ebola Infections [J].

Andrews, Chasity D. ;

Luo, Yang ;

Sun, Ming ;

Yu, Jian ;

Goff, Arthur J. ;

Glass, Pamela J. ;

Padte, Neal N. ;

Huang, Yaoxing ;

Ho, David D. .

MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT, 2017, 7 :74-82

[3] A Two-Antibody Pan-Ebolavirus Cocktail Confers Broad Therapeutic Protection in Ferrets and Nonhuman Primates [J].

Bornholdt, Zachary A. ;

Herbert, Andrew S. ;

Mire, Chad E. ;

He, Shihua ;

Cross, Robert W. ;

Wec, Anna Z. ;

Abelson, Dafna M. ;

Geisbert, Joan B. ;

James, Rebekah M. ;

Rahim, Niaz ;

Zhu, Wenjun ;

Borisevich, Viktoriya ;

Banadyga, Logan ;

Gunn, Bronwyn M. ;

Agans, Krystle N. ;

Wirchnianski, Ariel S. ;

Goodwin, Eileen ;

Tierney, Kevin ;

Shestowsky, William S. ;

Bohorov, Ognian ;

Bohorova, Natasha ;

Velasco, Jesus ;

Ailor, Eric ;

Kim, Do ;

Pauly, Michael H. ;

Whaley, Kevin J. ;

Alter, Galit ;

Walker, Laura M. ;

Chandran, Kartik ;

Zeitlin, Larry ;

Qiu, Xiangguo ;

Geisbert, Thomas W. ;

Dye, John M. .

CELL HOST & MICROBE, 2019, 25 (01) :49-+

[4] Post-exposure immunotherapy for two ebolaviruses and Marburg virus in nonhuman primates [J].

Brannan, Jennifer M. ;

He, Shihua ;

Howell, Katie A. ;

Prugar, Laura I. ;

Zhu, Wenjun ;

Hong Vu ;

Shulenin, Sergey ;

Kailasan, Shweta ;

Raina, Henna ;

Wong, Gary ;

Rahim, Md Niaz ;

Banadyga, Logan ;

Tierney, Kevin ;

Zhao, Xuelian ;

Li, Yuxing ;

Holtsberg, Frederick W. ;

Dye, John M. ;

Qiu, Xiangguo ;

Aman, M. Javad .

NATURE COMMUNICATIONS, 2019, 10 (1)

[5] Ebola hemorrhagic fever in Kikwit, Democratic Republic of the Congo: Clinical observations in 103 patients [J].

Bwaka, MA ;

Bonnet, MJ ;

Calain, P ;

Colebunders, R ;

De Roo, A ;

Guimard, Y ;

Katwiki, KR ;

Kibadi, K ;

Kipasa, MA ;

Kuvula, KJ ;

Mapanda, BB ;

Massamba, M ;

Mupapa, KD ;

Muyembe-Tamfum, JJ ;

Ndaberey, E ;

Peters, CJ ;

Rollin, PE ;

Van den Enden, E .

JOURNAL OF INFECTIOUS DISEASES, 1999, 179 :S1-S7

[6]

cdc, History of Ebola Virus Disease (EVD) Outbreaks

[7] Long-term sequelae after Ebola virus disease in Bundibugyo, Uganda: a retrospective cohort study [J].

Clark, Danielle V. ;

Kibuuka, Hannah ;

Millard, Monica ;

Wakabi, Salim ;

Lukwago, Luswa ;

Taylor, Alison ;

Eller, Michael A. ;

Eller, Leigh Anne ;

Michael, Nelson L. ;

Honko, Anna N. ;

Olinger, Gene G., Jr. ;

Schoepp, Randal J. ;

Hepburn, Matthew J. ;

Hensley, Lisa E. ;

Robb, Merlin L. .

LANCET INFECTIOUS DISEASES, 2015, 15 (08) :905-912

[8] Protective monotherapy against lethal Ebola virus infection by a potently neutralizing antibody [J].

Corti, Davide ;

Misasi, John ;

Mulangu, Sabue ;

Stanley, Daphne A. ;

Kanekiyo, Masaru ;

Wollen, Suzanne ;

Ploquin, Aurelie ;

Doria-Rose, Nicole A. ;

Staupe, Ryan P. ;

Bailey, Michael ;

Shi, Wei ;

Choe, Misook ;

Marcus, Hadar ;

Thompson, Emily A. ;

Cagigi, Alberto ;

Silacci, Chiara ;

Fernandez-Rodriguez, Blanca ;

Perez, Laurent ;

Sallusto, Federica ;

Vanzetta, Fabrizia ;

Agatic, Gloria ;

Cameroni, Elisabetta ;

Kisalu, Neville ;

Gordon, Ingelise ;

Ledgerwood, Julie E. ;

Mascola, John R. ;

Graham, Barney S. ;

Muyembe-Tamfun, Jean-Jacques ;

Trefry, John C. ;

Lanzavecchia, Antonio ;

Sullivan, Nancy J. .

SCIENCE, 2016, 351 (6279) :1339-1342

[9] A Randomized, Controlled Trial of ZMapp for Ebola Virus Infection [J].

Davey, Richard T., Jr. ;

Dodd, Lori ;

Proschan, Michael A. ;

Neaton, James ;

Nordwall, Jacquie Neuhaus ;

Koopmeiners, Joseph S. ;

Beigel, John ;

Tierney, John ;

Lane, H. Clifford ;

Fauci, Anthony S. ;

Massaquoi, Moses B. F. ;

Sahr, Foday ;

Malvy, Denis .

NEW ENGLAND JOURNAL OF MEDICINE, 2016, 375 (15) :1448-1456

[10] Ebola RNA Persistence in Semen of Ebola Virus Disease Survivors - Final Report [J].

Deen, G. F. ;

Broutet, N. ;

Xu, W. ;

Knust, B. ;

Sesay, F. R. ;

McDonald, S. L. R. ;

Ervin, E. ;

Marrinan, J. E. ;

Gaillard, P. ;

Habib, N. ;

Liu, H. ;

Liu, W. ;

Thorson, A. E. ;

Yamba, F. ;

Massaquoi, T. A. ;

James, F. ;

Ariyarajah, A. ;

Ross, C. ;

Bernstein, K. ;

Coursier, A. ;

Klena, J. ;

Carino, M. ;

Wurie, A. H. ;

Zhang, Y. ;

Dumbuya, M. S. ;

Abad, N. ;

Idriss, B. ;

Wi, T. ;

Bennett, S. D. ;

Davies, T. ;

Ebrahim, F. K. ;

Meites, E. ;

Naidoo, D. ;

Smith, S. J. ;

Ongpin, P. ;

Malik, T. ;

Banerjee, A. ;

Erickson, B. R. ;

Liu, Y. ;

Xu, K. ;

Brault, A. ;

Durski, K. N. ;

Winter, J. ;

Sealy, T. ;

Nichol, S. T. ;

Lamunu, M. ;

Bangura, J. ;

Landoulsi, S. ;

Jambai, A. .

NEW ENGLAND JOURNAL OF MEDICINE, 2017, 377 (15) :1428-1437

← 1 2 3 4 5 →