The difficult management of disseminated Sporothrix brasiliensis in a patient with advanced AIDS

被引：41

作者：

Paixao, Ariane Gomes ^{[1
]}

Gutierrez Galhardo, Maria Clara ^{[1
]}

Almeida-Paes, Rodrigo ^{[1
]}

Nunes, Estevao Portela ^{[1
]}

Carvalho Goncalves, Marcelo Luiz ^{[1
]}

Chequer, Gisele Larias ^{[1
]}

da Cruz Lamas, Cristiane ^{[1
]}

机构：

[1] Univ Grande Rio, FIOCRUZ, Fundacao Oswaldo Cruz, Rio De Janeiro, RJ, Brazil

来源：

AIDS RESEARCH AND THERAPY | 2015年 / 12卷

关键词：

Sporotrichosis; AIDS; Amphotericin B; Posaconazole; RIO-DE-JANEIRO; HIV-INFECTED PATIENTS; SPOROTRICHOSIS; BRAZIL; IMMUNODEFICIENCY;

D O I：

10.1186/s12981-015-0051-1

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Sporotrichosis is an infection caused by a dimorphic fungus of the Sporothrix schenckii complex. Host immunity is an important factor in the clinical manifestations of the disease. Deeply immunocompromised individuals, especially those infected with the Human Immunodeficiency Virus (HIV) and T CD4 counts <350 cells/ul lymphocytes, may present with the systemic form of sporotrichosis. This report describes a case of disseminated sporotrichosis caused by S. brasiliensis in a patient with advanced AIDS. The skin, lungs, bones and central nervous system were affected. Medical treatment involved the administration of amphotericin B, terbinafine, itraconazole and posaconazole. Posaconazole was associated with the best clinical response and clearing of the fungus from the central nervous system.

引用

页数：6

共 24 条

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