A practical diastereoselective synthesis of β-amino-α-hydroxy carboxylates

被引：15

作者：

Lee, JM ^{[1
]}

Lim, HS ^{[1
]}

Seo, KC ^{[1
]}

Chung, SK ^{[1
]}

机构：

[1] Pohang Univ Sci & Technol, Dept Chem, Div Mol & Life Sci, Pohang 790784, South Korea

来源：

TETRAHEDRON-ASYMMETRY | 2003年 / 14卷 / 23期

关键词：

D O I：

10.1016/j.tetasy.2003.10.009

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Practical synthetic routes to beta-amino-alpha-hydroxy carboxylates (AHC) have been developed from amino acids. Reduction of beta-amino-alpha-keto esters 6 with NaBH4 was found to give anti-AHCs 7 in high de, which were efficiently converted to the corresponding syn-AHCs 8 via oxazolidine ring 10 formation. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：3639 / 3641

页数：3

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