The Powerstroke and Camshaft of the RIG-I Antiviral RNA Detection Machine

被引：22

作者：

O'Neill, Luke A. J. ^{[1
]}

Bowie, Andrew G. ^{[1
]}

机构：

[1] Trinity Coll Dublin, Immunol Res Ctr, Sch Biochem & Immunol, Trinity Biomed Sci Inst, Dublin 2, Ireland

来源：

CELL | 2011年 / 147卷 / 02期

关键词：

INNATE IMMUNITY; RECOGNITION;

D O I：

10.1016/j.cell.2011.09.027

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The innate immune sensor RIG-I responds to infection by binding to viral double-stranded RNA (dsRNA). In this issue of Cell, Kowalinski et al. (2011) and Luo et al. (2011) reveal the structure of RIG-I, and in combination with functional analyses, they show how RIG-I recognizes viral RNA to initiate signaling and a type I interferon response.

引用

页码：259 / 261

页数：3

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