Rh-Catalyzed Asymmetric Hydroformylation of Functionalized 1,1-Disubstituted Olefins

被引：92

作者：

Wang, Xiao ^{[1
]}

Buchwald, Stephen L. ^{[1
]}

机构：

[1] MIT, Dept Chem, Cambridge, MA 02139 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2011年 / 133卷 / 47期

关键词：

HIGHLY ENANTIOSELECTIVE HYDROFORMYLATION; DIASTEREOSELECTIVE HYDROFORMYLATION; DIAZAPHOSPHOLANE LIGANDS; UNSATURATED ESTERS; PHOSPHITE LIGANDS; ALLYLIC ALCOHOLS; ALDOL SYNTHESIS; ARYL ALKENES; RHODIUM; HYDROGENATION;

D O I：

10.1021/ja2092689

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The first method for the highly enantioselective rhodium-catalyzed hydroformylation of 1,1-disubstituted olefins has been developed. By employing either of the P-chirogenic phosphine ligands BenzP* and QuinoxP*, linear aldehydes with beta-chirality can be prepared in a highly enantioselective fashion with good chemo- and regioselectivities.

引用

收藏

页码：19080 / 19083

页数：4

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