Rh-Catalyzed Asymmetric Hydroformylation of Functionalized 1,1-Disubstituted Olefins

被引：92
作者：
Wang, Xiao [1 ]
Buchwald, Stephen L. [1 ]
机构：
[1] MIT, Dept Chem, Cambridge, MA 02139 USA
来源：
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2011年 / 133卷 / 47期
关键词：
HIGHLY ENANTIOSELECTIVE HYDROFORMYLATION; DIASTEREOSELECTIVE HYDROFORMYLATION; DIAZAPHOSPHOLANE LIGANDS; UNSATURATED ESTERS; PHOSPHITE LIGANDS; ALLYLIC ALCOHOLS; ALDOL SYNTHESIS; ARYL ALKENES; RHODIUM; HYDROGENATION;
D O I：
10.1021/ja2092689
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The first method for the highly enantioselective rhodium-catalyzed hydroformylation of 1,1-disubstituted olefins has been developed. By employing either of the P-chirogenic phosphine ligands BenzP* and QuinoxP*, linear aldehydes with beta-chirality can be prepared in a highly enantioselective fashion with good chemo- and regioselectivities.
引用
收藏
页码：19080 / 19083
页数：4
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