Diagnosis of Indigenous Non-Malarial Vector-Borne Infections from Malaria Negative Samples from Community and Rural Hospital Surveillance in Dhalai District, Tripura, North-East India

被引：5

作者：

Bhowmick, Ipsita Pal ^{[1
]}

Pandey, Apoorva ^{[2
]}

Subbarao, Sarala K. ^{[3
]}

Pebam, Rocky ^{[4
]}

Majumder, Tapan ^{[5
]}

Nath, Aatreyee ^{[4
]}

Nandi, Diptarup ^{[6
]}

Basu, Analabha ^{[6
]}

Sarkar, Apurba ^{[5
]}

Majumder, Saikat ^{[5
]}

Debbarma, Jotish ^{[1
]}

Dasgupta, Dipanjan ^{[1
]}

Borgohain, Arup ^{[4
]}

Chanda, Rajdeep ^{[7
]}

Das, Mandakini ^{[1
,8
]}

Gogoi, Karuna ^{[1
]}

Gogoi, Kongkona ^{[1
]}

Joshi, Pyare Laal ^{[9
]}

Kaur, Harpreet ^{[2
]}

Borkakoti, Biswajyoti ^{[1
]}

Ranjan Bhattacharya, Dibya ^{[1
]}

Khan, Abdul Mamood ^{[2
]}

Sen, Satyajit ^{[10
]}

Narain, Kanwar ^{[1
]}

机构：

[1] Reg Med Res Ctr Northeast Reg RMRC NE, ICMR, Dibrugarh 786001, India

[2] Indian Council Med Res ICMR, Ramalingaswami Bhavan, New Delhi 110029, India

[3] Indian Council Med Res ICMR, Natl Inst Malaria Res, New Delhi 110029, India

[4] Govt India Umiam, North Eastern Space Applicat Ctr, Dept Space, Umiam 793103, India

[5] Agartala Govt Med Coll, Dept Microbiol, Agartala 799006, India

[6] Natl Inst BioMed Genom, Kalyani 741251, India

[7] Mizoram Univ, Dept Forestry, Aizawl 796004, India

[8] Roche Diagnost India Pvt Ltd, Mumbai 400069, Maharashtra, India

[9] Natl Vector Borne Dis Control Program NV, New Delhi 110054, India

[10] Reg Off Hlth & Family Welf, Kolkata 700106, India

来源：

DIAGNOSTICS | 2022年 / 12卷 / 02期

关键词：

acute febrile illness; infectious diseases; malaria; non-malaria vector-borne diseases; Dengue; Chikungunya; Japanese encephalitis; scrub typhus; leptospirosis; malaria-endemic region; community fever surveillance; ACUTE ENCEPHALITIS SYNDROME; DENGUE VIRUS; SCRUB TYPHUS; ARUNACHAL-PRADESH; FEVER; PREVALENCE; VIVAX; ASSAM;

D O I：

10.3390/diagnostics12020362

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The aetiology of non-malaria vector-borne diseases in malaria-endemic, forested, rural, and tribal-dominated areas of Dhalai, Tripura, in north-east India, was studied for the first time in the samples collected from malaria Rapid Diagnostic Kit negative febrile patients by door-to-door visits in the villages and primary health centres. Two hundred and sixty serum samples were tested for the Dengue NS1 antigen and the IgM antibodies of Dengue, Chikungunya, Scrub Typhus (ST), and Japanese Encephalitis (JE) during April 2019-March 2020. Fifteen Dengue, six JE, twelve Chikungunya, nine ST and three Leptospirosis, and mixed infections of three JE + Chikungunya, four Dengue + Chikungunya, three Dengue + JE + Chikungunya, one Dengue + Chikungunya + ST, and one Dengue + ST were found positive by IgM ELISA tests, and four for the Dengue NS1 antigen, all without any travel history. True prevalence values estimated for infections detected by Dengue IgM were 0.134 (95% CI: 0.08-0.2), Chikungunya were 0.084 (95% CI: 0.05-0.13), Scrub were 0.043 (95% CI: 0.01-0.09), and Japanese Encephalitis were 0.045 (95% CI: 0.02-0.09). Dengue and Chikungunya were associated significantly more with a younger age. There was a lack of a defined set of symptoms for any of the Dengue, Chikungunya, JE or ST infections, as indicated by the k-modes cluster analysis. Interestingly, most of these symptoms have an overlapping set with malaria; thereby, it becomes imperative that malaria and these non-malaria vector-borne disease diagnoses are made in a coordinated manner. Findings from this study call for advances in routine diagnostic procedures and the development of a protocol that can accommodate, currently, in practicing the rapid diagnosis of malaria and other vector-borne diseases, which is doable even in the resource-poor settings of rural hospitals and during community fever surveillance.

引用

页数：19

共 45 条

[1] Multi-Omics Advancements towards Plasmodium vivax Malaria Diagnosis [J].

Aggarwal, Shalini ;

Peng, Weng Kung ;

Srivastava, Sanjeeva .

DIAGNOSTICS, 2021, 11 (12)

[2] Reduction in malaria prevalence and increase in malaria awareness in endemic districts of Bangladesh [J].

Alam, Mohammad Shafiul ;

Kabir, Mohammad Moktadir ;

Hossain, Mohammad Sharif ;

Naher, Shamsun ;

Ferdous, Nur E. Naznin ;

Khan, Wasif Ali ;

Mondal, Dinesh ;

Karim, Jahirul ;

Shamsuzzaman, A. K. M. ;

Ahmed, Be-Nazir ;

Islam, Akramul ;

Haque, Rashidul .

MALARIA JOURNAL, 2016, 15 :1-7

[3] Magneto-optical diagnosis of symptomatic malaria in Papua New Guinea [J].

Arndt, L. ;

Koleala, T. ;

Orban, A. ;

Ibam, C. ;

Lufele, E. ;

Timinao, L. ;

Lorry, L. ;

Butykai, A. ;

Kaman, P. ;

Molnar, A. P. ;

Krohns, S. ;

Nate, E. ;

Kucsera, I ;

Orosz, E. ;

Moore, B. ;

Robinson, L. J. ;

Laman, M. ;

Kezsmarki, I ;

Karl, S. .

NATURE COMMUNICATIONS, 2021, 12 (01)

[4] Approach to acute febrile illness during the COVID-19 pandemic [J].

Bhatt, Manasvini ;

Soneja, Manish ;

Gupta, Nitin .

DRUG DISCOVERIES AND THERAPEUTICS, 2020, 14 (06) :282-286

[5] Dry Post Wintertime Mass Surveillance Unearths a Huge Burden of P. vivax, and Mixed Infection with P. vivax P. falciparum, a Threat to Malaria Elimination, in Dhalai, Tripura, India [J].

Bhowmick, Ipsita Pal ;

Nirmolia, Tulika ;

Pandey, Apoorva ;

Subbarao, Sarala K. ;

Nath, Aatreyee ;

Senapati, Susmita ;

Tripathy, Debabrata ;

Pebam, Rocky ;

Nag, Suman ;

Roy, Rajashree ;

Dasgupta, Dipanjan ;

Debnath, Jayanta ;

Gogoi, Kongkona ;

Gogoi, Karuna ;

Borah, Lakhyajit ;

Chanda, Rajdeep ;

Borgohain, Arup ;

Mog, Chelapro ;

Sarkar, Ujjwal ;

Gogoi, Phiroz ;

Debnath, Bishal ;

Debbarma, Jyotish ;

Ranjan Bhattacharya, Dibya ;

Joshi, Pyare Lal ;

Kaur, Harpreet ;

Narain, Kanwar .

PATHOGENS, 2021, 10 (10)

[6] Diagnostic Accuracy of the InBios Scrub Typhus Detect (TM) ELISA for the Detection of IgM Antibodies in Chittagong, Bangladesh [J].

Blacksell, Stuart D. ;

Kingston, Hugh W. F. ;

Tanganuchitcharnchai, Ampai ;

Phanichkrivalkosil, Meghna ;

Hossain, Mosharraf ;

Hossain, Amir ;

Ghose, Aniruddha ;

Leopold, Stije J. ;

Dondorp, Arjen M. ;

Day, Nicholas P. J. ;

Paris, Daniel H. .

TROPICAL MEDICINE AND INFECTIOUS DISEASE, 2018, 3 (03)

[7] Diagnostic Accuracy of the InBios Scrub Typhus Detect Enzyme-Linked Immunoassay for the Detection of IgM Antibodies in Northern Thailand [J].

Blacksell, Stuart D. ;

Tanganuchitcharnchai, Ampai ;

Nawtaisong, Pruksa ;

Kantipong, Pacharee ;

Laongnualpanich, Achara ;

Day, Nicholas P. J. ;

Paris, Daniel H. .

CLINICAL AND VACCINE IMMUNOLOGY, 2016, 23 (02) :148-154

[8]

Borkakoty B, 2018, INDIAN J MED MICROBI, V36, P37, DOI [10.4103/ijmm.IJMM_17_30, 10.4103/ijmm.ijmm_17_30]

[9] Co-infection of scrub typhus and leptospirosis in patients with pyrexia of unknown origin in Longding district of Arunachal Pradesh in 2013 [J].

Borkakoty, Biswajyoti ;

Jakharia, Aniruddha ;

Biswas, Dipankar ;

Mahanta, Jagadish .

INDIAN JOURNAL OF MEDICAL MICROBIOLOGY, 2016, 34 (01) :88-91

[10] Towards ultrasensitive malaria diagnosis using surface enhanced Raman spectroscopy [J].

Chen, Keren ;

Yuen, Clement ;

Aniweh, Yaw ;

Preiser, Peter ;

Liu, Quan .

SCIENTIFIC REPORTS, 2016, 6

← 1 2 3 4 5 →