Thieno[2,3-d]pyrimidine derivatives: Synthetic approaches and their FLT3 kinase inhibition

被引：10
作者：
Elmongy, Elshaymaa, I [1 ,2 ]
机构：
[1] Helwan Univ, Fac Pharm, Dept Pharmaceut Chem, POB 11795, Cairo, Egypt
[2] Princess Nourah Bint Abdulrahman Univ, Fac Pharm, Dept Pharmaceut Sci, Riyadh, Saudi Arabia
来源：
JOURNAL OF HETEROCYCLIC CHEMISTRY | 2020年 / 57卷 / 05期
关键词：
ACUTE MYELOGENOUS LEUKEMIA; GROWTH-FACTOR RECEPTOR; BIOLOGICAL EVALUATION; CONVENIENT SYNTHESIS; MUTATIONS; GENE; 2-AMINOTHIOPHENE-3-CARBOXAMIDE; HETEROCYCLES; PREVALENCE; CHEMISTRY;
D O I：
10.1002/jhet.3934
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Thienopyrimidines are popular purine bioisosteres, a fundamental piece of the human metabolome. The structural similarity of this scaffold with nucleobases in the nucleic acid of DNA made it an interesting moiety to be used in the design of kinase inhibitors. This review focuses on the chemistry of thieno[2,3-d]pyrimidine derivatives and their potential activities against Fms-like tyrosine kinase (FLT3kinase) in addition to their structure-activity relationship studies.
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页码：2067 / 2078
页数：12
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