Thieno[2,3-d]pyrimidine derivatives: Synthetic approaches and their FLT3 kinase inhibition

被引：10

作者：

Elmongy, Elshaymaa, I ^{[1
,2
]}

机构：

[1] Helwan Univ, Fac Pharm, Dept Pharmaceut Chem, POB 11795, Cairo, Egypt

[2] Princess Nourah Bint Abdulrahman Univ, Fac Pharm, Dept Pharmaceut Sci, Riyadh, Saudi Arabia

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 2020年 / 57卷 / 05期

关键词：

ACUTE MYELOGENOUS LEUKEMIA; GROWTH-FACTOR RECEPTOR; BIOLOGICAL EVALUATION; CONVENIENT SYNTHESIS; MUTATIONS; GENE; 2-AMINOTHIOPHENE-3-CARBOXAMIDE; HETEROCYCLES; PREVALENCE; CHEMISTRY;

D O I：

10.1002/jhet.3934

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Thienopyrimidines are popular purine bioisosteres, a fundamental piece of the human metabolome. The structural similarity of this scaffold with nucleobases in the nucleic acid of DNA made it an interesting moiety to be used in the design of kinase inhibitors. This review focuses on the chemistry of thieno[2,3-d]pyrimidine derivatives and their potential activities against Fms-like tyrosine kinase (FLT3kinase) in addition to their structure-activity relationship studies.

引用

页码：2067 / 2078

页数：12

共 65 条

[1] Recent Report on Thieno[2,3-d]pyrimidines. Their Preparation Including Microwave and Their Utilities in Fused Heterocycles Synthesis [J].

Aly, Ashraf A. ;

Ishak, Esam A. ;

Ramadan, Mohamed ;

Germoush, Mousa O. ;

El-Emary, Talaat I. ;

Al-Muaikel, Nayef S. .

JOURNAL OF HETEROCYCLIC CHEMISTRY, 2013, 50 (03) :451-472

[2]

[Anonymous], BLOOD

[3] N-cyanochloroacetamidine - A convenient reagent for the regioselective synthesis of fused diaminopyrimidines. [J].

Artyomov, VA ;

Rodinovskaya, LA ;

Shestopalov, AM ;

Litvinov, VP .

TETRAHEDRON, 1996, 52 (03) :1011-1026

[4] Discovery of Potent VEGFR-2 Inhibitors based on Furopyrimidine and Thienopyrimidne Scaffolds as Cancer Targeting Agents [J].

Aziz, Marwa A. ;

Serya, Rabah A. T. ;

Lasheen, Deena S. ;

Abdel-Aziz, Amal Kamal ;

Esmat, Ahmed ;

Mansour, Ahmed M. ;

Singab, Abdel Nasser B. ;

Abouzid, Khaled A. M. .

SCIENTIFIC REPORTS, 2016, 6

[5]

BOHM N, 1992, PHARMAZIE, V47, P897

[6]

BOHM R, 1990, PHARMAZIE, V45, P827

[7] Recent developments regarding the use of thieno[2,3-d]pyrimidin-4-one derivatives in medicinal chemistry, with a focus on their synthesis and anticancer properties [J].

Bozorov, Khurshed ;

Zhao, Jiang-Yu ;

Elmuradov, Burkhon ;

Pataer, Apar ;

Aisa, Haji A. .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2015, 102 :552-573

[8]

BRIEL D, 1992, PHARMAZIE, V47, P577

[9] SYNTHESIS OF THIENO[2,3-D]PYRIMIDINES FROM 4,6-DICHLOROPYRIMIDINE-5-CARBALDEHYDES [J].

CLARK, J ;

SHAHHET, MS ;

KORAKAS, D ;

VARVOUNIS, G .

JOURNAL OF HETEROCYCLIC CHEMISTRY, 1993, 30 (04) :1065-1072

[10] Diethyl ethoxymethylenemalonate in triheterocycles: A new synthesis of pyrido[3,2-e]pyrimido[1,2-c]pyrimidines [J].

Dave, CG ;

Shukla, MC .

JOURNAL OF HETEROCYCLIC CHEMISTRY, 1997, 34 (06) :1805-1808

← 1 2 3 4 5 6 7 →