Adipose Tissue-Liver Cross Talk in the Control of Whole-Body Metabolism: Implications in Nonalcoholic Fatty Liver Disease

被引：247
作者：
Azzu, Vian [1 ,2 ]
Vacca, Michele [1 ]
Virtue, Samuel [1 ]
Allison, Michael E. D. [2 ]
Vidal-Puig, Antonio [1 ,3 ]
机构：
[1] Wellcome Trust Med Res Council, Addenbrookes Hosp, Inst Metab Sci, Metab Res Labs, Level 4,Box 289, Cambridge CB2 0QQ, England
[2] Cambridge Univ Hosp Natl Hlth Serv Fdn Trust, Dept Med, Liver Unit, Cambridge Biomed Campus,Hills Rd, Cambridge, England
[3] Wellcome Trust Sanger Inst, Hinxton, England
来源：
GASTROENTEROLOGY | 2020年 / 158卷 / 07期
基金：
英国医学研究理事会; 英国生物技术与生命科学研究理事会; 欧盟地平线“2020”;
关键词：
LIPOPROTEIN-LIPASE ACTIVITY; REVERSES INSULIN-RESISTANCE; SUPERFAMILY MEMBER 2; CD4(+) T-CELLS; HEPATIC STEATOSIS; LIPID-METABOLISM; ACID-METABOLISM; GENE-EXPRESSION; MASS INDEX; OBESITY;
D O I：
10.1053/j.gastro.2019.12.054
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Adipose tissue and the liver play significant roles in the regulation of whole-body energy homeostasis, but they have not evolved to cope with the continuous, chronic, nutrient surplus seen in obesity. In this review, we detail how prolonged metabolic stress leads to adipose tissue dysfunction, inflammation, and adipokine release that results in increased lipid flux to the liver. Overall, the upshot of hepatic fat accumulation alongside an insulin-resistant state is that hepatic lipid enzymatic pathways are modulated and overwhelmed, resulting in the selective buildup of toxic lipid species, which worsens the pro-inflammatory and pro-fibrotic shift observed in nonalcoholic steatohepatitis. © 2020 AGA Institute
引用
收藏
页码：1899 / 1912
页数：14
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