NCCN Guidelines® Insights Central Nervous System Cancers, Version 1.2017 Featured Updates to the NCCN Guidelines

被引：147

作者：

Nabors, Louis Burt ^{[1
]}

Portnow, Jana ^{[2
]}

Ammirati, Mario ^{[3
,4
]}

Baehring, Joachim ^{[5
]}

Brem, Henry ^{[6
]}

Butowski, Nicholas ^{[7
]}

Fenstermaker, Robert A. ^{[8
]}

Forsyth, Peter ^{[9
]}

Hattangadi-Gluth, Jona ^{[10
]}

Holdhoff, Matthias

Howard, Steven ^{[11
]}

Junck, Larry ^{[12
]}

Kaley, Thomas ^{[13
]}

Kumthekar, Priya ^{[14
]}

Loeffler, Jay S. ^{[15
]}

Moots, Paul L. ^{[16
]}

Mrugala, Maciej M. ^{[17
]}

Nagpal, Seema ^{[18
]}

Pandey, Manjari ^{[19
]}

Parney, Ian ^{[17
]}

Peters, Katherine ^{[20
]}

Puduvalli, Vinay K. ^{[3
,4
]}

Ragsdale, John, III ^{[20
]}

Rockhill, Jason ^{[21
]}

Rogers, Lisa ^{[22
,23
]}

Rusthoven, Chad ^{[24
]}

Shonka, Nicole ^{[25
]}

Shrieve, Dennis C. ^{[26
]}

Sills, Allen K., Jr. ^{[16
]}

Swinnen, Lode J.

Tsien, Christina ^{[27
]}

Weiss, Stephanie ^{[28
]}

Wen, Patrick Yung ^{[29
]}

Willmarth, Nicole ^{[30
]}

Bergman, Mary Anne ^{[31
]}

Engh, Anita ^{[31
]}

机构：

[1] Univ Alabama Birmingham, Comprehens Canc Center, Tuscaloosa, AL 35487 USA

[2] City Hope Comprehens Canc Ctr, Duarte, CA USA

[3] Ohio State Univ, Comprehens Canc Ctr, James Canc Hosp, Columbus, OH 43210 USA

[4] Solove Res Inst, Columbus, OH 43210 USA

[5] Smilow Canc Hosp, Yale Canc Ctr, Haven, CT USA

[6] Sidney Kimmel Comprehens Canc Ctr Johns Hopkins, Baltimore, MD USA

[7] UCSF, Helen Diller Family Comprehens Canc Ctr, San Francisco, CA USA

[8] Roswell Pk Canc Inst, Buffalo, NY USA

[9] H Lee Moffitt Canc Ctr & Res Inst, Tampa, FL USA

[10] UC San Diego Moores Canc Ctr, San Diego, CA USA

[11] Univ Wisconsin, Carbone Canc Ctr, Madison, WI 53706 USA

[12] Univ Michigan, Comprehens Canc Ctr, Ann Arbor, MI 48109 USA

[13] Mem Sloan Kettering Canc Ctr, New York, NY USA

[14] Northwestern Univ, Robert H Lurie Comprehens Canc Ctr, Evanston, IL 60208 USA

[15] Massachusetts Gen Hosp, Canc Ctr, Boston, MA 02114 USA

[16] Vanderbilt Ingram Canc Ctr, Nashville, TN USA

[17] Mayo Clin, Canc Ctr, Rochester, MN USA

[18] Stanford Canc Inst, Stanford, CA USA

[19] Univ Tennessee, Hlth Sci Ctr, St Jude Childrens Res Hosp, Knoxville, TN 37996 USA

[20] Duke Canc Inst, Durham, NC USA

[21] Univ Washington, Seattle Canc Care Alliance, Seattle, WA 98195 USA

[22] Univ Hosp Seidman Canc Ctr, Case Comprehens Canc Ctr, Cleveland, OH USA

[23] Cleveland Clin, Taussig Canc Inst, Cleveland, OH USA

[24] Univ Colorado, Canc Ctr, Boulder, CO 80309 USA

[25] Fred & Pamela Buffet Canc Ctr, Omaha, NE USA

[26] Univ Utah, Huntsman Canc Inst, Salt Lake City, UT 84112 USA

[27] Washington Univ, Sch Med, Siteman Canc Ctr, Barnes Jewish Hosp, St Louis, MO 63130 USA

[28] Fox Chase Canc Ctr, Philadelphia, PA USA

[29] Brigham & Womens Canc Ctr, Dana Farber Canc Inst, Boston, MA USA

[30] Amer Brain Tumor Assoc, Chicago, IL USA

[31] Natl Comprehens Canc Network, Ft Washington, PA USA

来源：

JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK | 2017年 / 15卷 / 11期

关键词：

PHASE-III TRIAL; DIAGNOSED ANAPLASTIC OLIGODENDROGLIOMA; RANDOMIZED EUROPEAN-ORGANIZATION; LOW-GRADE GLIOMAS; IDH2; MUTATIONS; MOLECULAR CLASSIFICATION; ADJUVANT PROCARBAZINE; CLINICAL-TRIALS; 1P/19Q LOSS; CHEMOTHERAPY;

D O I：

10.6004/jnccn.2017.0166

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

For many years, the diagnosis and classification of gliomas have been based on histology. Although studies including large populations of patients demonstrated the prognostic value of histologic phenotype, variability in outcomes within histologic groups limited the utility of this system. Nonetheless, histology was the only proven and widely accessible tool available at the time, thus it was used for clinical trial entry criteria, and therefore determined the recommended treatment options. Research to identify molecular changes that underlie glioma progression has led to the discovery of molecular features that have greater diagnostic and prognostic value than histology. Analyses of these molecular markers across populations from randomized clinical trials have shown that some of these markers are also predictive of response to specific types of treatment, which has prompted significant changes to the recommended treatment options for grade III (anaplastic) gliomas.

引用

页码：1331 / 1345

页数：15

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