Mitochondrial GSDMD Pores DAMPen Pyroptosis

被引：39

作者：

Barnett, Katherine C. ^{[1
]}

Ting, Jenny P. -Y. ^{[1
]}

机构：

[1] Univ N Carolina, Chapel Hill, NC 27515 USA

来源：

IMMUNITY | 2020年 / 52卷 / 03期

关键词：

UPSTREAM;

D O I：

10.1016/j.immuni.2020.02.012

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Noncanoncial inflammasome activation by cytosolic lipopolysaccharide (LPS) causes pyroptotic cell death facilitated by gasdermin D (GSDMD) pore formation. In this issue of Immunity, Huang et al. describe how cytosolic LPS in endothelial cells does not cause cell death but restrains endothelial cell proliferation.

引用

收藏

页码：424 / 426

页数：3

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