Ethical issues related to brain organoid research

被引：68
作者：
Hyun, Insoo [1 ]
Scharf-Deering, J. C. [1 ]
Lunshof, Jeantine E. [2 ,3 ,4 ]
机构：
[1] Case Western Reserve Univ, Cleveland, OH 44106 USA
[2] Harvard, Wyss Inst Biol Inspired Engn, Cambridge, MA USA
[3] Harvard Med Sch, Harvard Ctr Bioeth, Boston, MA 02115 USA
[4] Univ Groningen, Univ Med Ctr Groningen, Groningen, Netherlands
来源：
BRAIN RESEARCH | 2020年 / 1732卷
关键词：
Brain organoids; Ethics; Research oversight; Consent; Animal research; Consciousness; CEREBRAL ORGANOIDS; STEM-CELLS; PROGRESS; MODEL; DIFFERENTIATION; PROSPECTS;
D O I：
10.1016/j.brainres.2020.146653
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
This review provides a snapshot of the current ethical issues related to research with human brain organoids. The issues fall into the following main themes: research oversight; human biomaterials procurement and donor consent; translational delivery; animal research; and organoid consciousness and moral status. Each of these areas poses challenges for researchers, bioethicists, regulators, research institutions, and tissue banks. However, progress can be made if these parties build on past experiences with stem cell research, ethics, and policy, but adapted accordingly to new aspects of brain organoid research.
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页数：7
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