Cross-Coupling of Chloro(hetero)arenes with Thiolates Employing a Ni(0)-Precatalyst

被引：39

作者：

Gehrtz, Paul H. ^{[1
]}

Geiger, Valentin ^{[1
]}

Schmidt, Tanno ^{[1
]}

Srsan, Laura ^{[1
]}

Fleischer, Ivana ^{[1
]}

机构：

[1] Eberhard Karls Univ Tubingen, Fac Sci & Math, Inst Organ Chem, Morgenstelle 18, D-72076 Tubingen, Germany

来源：

ORGANIC LETTERS | 2019年 / 21卷 / 01期

关键词：

CARBON-SULFUR; TRANSITION-METAL; ARYL CHLORIDES; NICKEL; HALIDES; BOND; THIOETHERIFICATION; SULFIDES; COMPLEX;

D O I：

10.1021/acs.orglett.8b03476

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A general and efficient Ni-catalyzed coupling of challenging aryl chlorides and in situ generated aliphatic and aromatic thiolates is described. The employed on-cycle, air-stable defined Ni precatalysts allow for transformation of a broad scope of substrates. A variety of functional groups and heterocyclic motifs as well as structurally varied thiols are tolerated at unprecedented moderate catalyst loadings and reaction temperatures. Depending on reaction conditions, aryl thiols can selectively undergo C-S or C-C couplings.

引用

页码：50 / 55

页数：6

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