Site-Specific Chemical Modification of Peptide and Protein by Thiazolidinediones

被引：31

作者：

Wang, Peng

Zhang, Shumei

Meng, Qiuyue

Liu, Ying

Shang, Luqing ^{[1
]}

Yin, Zheng

机构：

[1] Nankai Univ, Coll Pharm, Collaborat Innovat Ctr Chem Sci & Engn Tianjin, Tianjin 300071, Peoples R China

来源：

ORGANIC LETTERS | 2015年 / 17卷 / 06期

基金：

中国国家自然科学基金;

关键词：

BIOMIMETIC TRANSAMINATION REACTION; BIOORTHOGONAL CHEMISTRY; ALDOL REACTIONS; OXIME LIGATION; BIOCONJUGATION; ALKYLATION; CYSTEINES; HYDRAZONE; CATALYSIS; ALDEHYDE;

D O I：

10.1021/acs.orglett.5b00005

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A direct aldol reaction employing 2,4-thiazolidinediones as nucleophilic donors was performed to modify peptides and protein under mild conditions. Various functional groups could be readily introduced into protein without conformation change.

引用

页码：1361 / 1364

页数：4

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