Site-Specific Chemical Modification of Peptide and Protein by Thiazolidinediones

被引：31
|
作者：
Wang, Peng
Zhang, Shumei
Meng, Qiuyue
Liu, Ying
Shang, Luqing [1 ]
Yin, Zheng
机构：
[1] Nankai Univ, Coll Pharm, Collaborat Innovat Ctr Chem Sci & Engn Tianjin, Tianjin 300071, Peoples R China
来源：
ORGANIC LETTERS | 2015年 / 17卷 / 06期
基金：
中国国家自然科学基金;
关键词：
BIOMIMETIC TRANSAMINATION REACTION; BIOORTHOGONAL CHEMISTRY; ALDOL REACTIONS; OXIME LIGATION; BIOCONJUGATION; ALKYLATION; CYSTEINES; HYDRAZONE; CATALYSIS; ALDEHYDE;
D O I：
10.1021/acs.orglett.5b00005
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A direct aldol reaction employing 2,4-thiazolidinediones as nucleophilic donors was performed to modify peptides and protein under mild conditions. Various functional groups could be readily introduced into protein without conformation change.
引用
收藏
页码：1361 / 1364
页数：4
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