Incidence of pneumococcal disease due to non-pneumococcal conjugate vaccine (PCV7) serotypes in the united states during the era of widespread PCV7 vaccination, 1998-2004

被引:608
|
作者
Hicks, Lauri A.
Harrison, Lee H.
Flannery, Brendan
Hadler, James L.
Schaffner, William
Craig, Allen S.
Jackson, Delois
Thomas, Ann
Beall, Bernard
Lynfield, Ruth
Reingold, Arthur
Farley, Monica M.
Whitney, Cynthia G.
机构
[1] Ctr Dis Control & Prevent, Resp Dis Branch, Atlanta, GA USA
[2] Ctr Dis Control & Prevent, Epidem Intelligence Serv, Atlanta, GA USA
[3] Emory Univ, Sch Med, Atlanta, GA 30322 USA
[4] Vet Affairs Med Ctr, Atlanta, GA 30033 USA
[5] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Baltimore, MD USA
[6] Connecticut Dept Publ Hlth & Addict Serv, Hartford, CT 06106 USA
[7] Vanderbilt Univ, Sch Med, Dept Prevent Med, Nashville, TN 37212 USA
[8] Tennessee Dept Hlth, Nashville, TN USA
[9] Oregon Publ Hlth Div, Portland, OR USA
[10] Minnesota Dept Hlth, St Paul, MN USA
[11] Univ Calif Berkeley, Sch Publ Hlth, Berkeley, CA 94720 USA
来源
JOURNAL OF INFECTIOUS DISEASES | 2007年 / 196卷 / 09期
关键词
D O I
10.1086/521626
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Background. Widespread use of pneumococcal conjugate vaccine (PCV7) resulted in decreases in invasive disease among children and elderly persons. The benefits may be offset by increases in disease due to serotypes not included in the vaccine (hereafter, "nonvaccine serotypes"). We evaluated the effect of PCV7 on incidence of disease due to nonvaccine serotypes. Methods. Cases of invasive disease were identified in 8 geographic areas through the Centers for Disease Control and Prevention's Active Bacterial Core surveillance. Serotyping and susceptibility testing of isolates were performed. We calculated the incidence of disease for children aged ! 5 years and adults aged >= 65 years. We compared rates of serotype-specific disease before and after PCV7 was licensed for use. Results. The annual incidence of disease due to nonvaccine serotypes increased from an average of 16.3 cases/100,000 population during prevaccine years (1998 - 1999) to 19.9 cases/100,000 population in 2004 for children aged <5 years (P = .01) and from 27.0 cases/100,000 population during prevaccine years to 29.8 cases/100,000 population in 2004 for adults aged >= 65 years (P = .05). Significant increases in the incidences of disease due to serotypes 3, 15, 19A, 22F, and 33F were observed among children during this period (for each serotype); P < .05 serotype 19A has become the predominant cause of invasive disease in children. The incidence of disease due to these serotypes also increased among elderly persons. Conclusions. The incidence of pneumococcal disease caused by nonvaccine serotypes is increasing. Ongoing surveillance is needed to monitor the magnitude of disease caused by nonvaccine serotypes, to ensure that future vaccines target the appropriate serotypes.
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页码:1346 / 1354
页数:9
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