Impact of Cold Ischemia on Renal Transplant Outcomes Following Donation After Cardiac Death

被引：8

作者：

Pine, J. K. ^{[1
]}

Goldsmith, P. J. ^{[1
]}

Ridgway, D. M. ^{[1
]}

Baker, R. ^{[1
]}

Newstead, C. G. ^{[1
]}

Pollard, S. G. ^{[1
]}

Menon, K. V. ^{[1
]}

Ahmad, N. ^{[1
]}

Attia, M. ^{[1
]}

机构：

[1] St James Univ Hosp, Dept Transplant Surg, Leeds LS9 7TF, W Yorkshire, England

来源：

TRANSPLANTATION PROCEEDINGS | 2010年 / 42卷 / 10期

关键词：

DELAYED GRAFT FUNCTION; ALLOGRAFT SURVIVAL; RISK-FACTORS; KIDNEYS; DONORS;

D O I：

10.1016/j.transproceed.2010.10.004

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Donation after cardiac death (DCD) provides grafts in renal transplantation but is associated with increased early graft dysfunction. Cold ischemia time (CIT) is a factor that is thought to affect outcomes in renal transplantation. We sought to assess the impact of the length of CIT among our DCD cohort of renal transplants performed between April 2002 and December 2009. Since the median CIT was 15.5 hours, we formed two groups CIT < 15.5 (n = 100) and CIT > 15.5 hr (n = 98). We demonstrated an increased incidence of DGF among the extended CIT group, but the long outcomes and the mean graft function were otherwise comparable. In conclusion, CIT affects early graft function; every effort should be made to minimize it in renal transplantation using DCD kidneys.

引用

页码：3951 / 3953

页数：3

共 9 条

[1] Case-matched comparison of long-term results of non-heart beating and heart-beating donor renal transplants [J].

Barlow, A. D. ;

Metcalfe, M. S. ;

Johari, Y. ;

Elwell, R. ;

Veitch, P. S. ;

Nicholson, M. L. .

BRITISH JOURNAL OF SURGERY, 2009, 96 (06) :685-691

[2] Transplantation of kidneys from donors whose hearts have stopped beating [J].

Cho, YW ;

Terasaki, PI ;

Cecka, JM ;

Gjertson, DW .

NEW ENGLAND JOURNAL OF MEDICINE, 1998, 338 (04) :221-225

[3] Risk factors for delayed graft function after renal transplantation and their significance for long-term clinical outcome [J].

Hetzel, GR ;

Klein, B ;

Brause, M ;

Westhoff, A ;

Willers, R ;

Sandmann, W ;

Grabensee, B .

TRANSPLANT INTERNATIONAL, 2002, 15 (01) :10-16

[4] Outcomes of kidneys from donors after cardiac death: Implications for allocation and preservation [J].

Locke, J. E. ;

Segev, D. L. ;

Warren, D. S. ;

Dominici, F. ;

Simpkins, C. E. ;

Montgomery, R. A. .

AMERICAN JOURNAL OF TRANSPLANTATION, 2007, 7 (07) :1797-1807

[5] Delayed graft function: Risk factors and implications for renal allograft survival [J].

Ojo, AO ;

Wolfe, RA ;

Held, PJ ;

Port, FK ;

Schmouder, RL .

TRANSPLANTATION, 1997, 63 (07) :968-974

[6] Major effects of delayed graft function and cold ischaemia time on renal allograft survival [J].

Quiroga, Isabel ;

McShane, Philip ;

Koo, Dicken D. H. ;

Gray, Derek ;

Friend, Peter J. ;

Fuggle, Susan ;

Darby, Christopher .

NEPHROLOGY DIALYSIS TRANSPLANTATION, 2006, 21 (06) :1689-1696

[7] THE QUALITY-OF-LIFE IN RENAL-TRANSPLANTATION - A PROSPECTIVE-STUDY [J].

RUSSELL, JD ;

BEECROFT, ML ;

LUDWIN, D ;

CHURCHILL, DN .

TRANSPLANTATION, 1992, 54 (04) :656-660

[8] Outcome of kidney transplantation using expanded criteria donors and donation after cardiac death kidneys: Realities and costs [J].

Saidi, R. F. ;

Elias, N. ;

Kawai, T. ;

Hertl, M. ;

Farrell, M.-L. ;

Goes, N. ;

Wong, W. ;

Hartono, C. ;

Fishman, J. A. ;

Kotton, C. N. ;

Tolkoff-Rubin, N. ;

Delmonico, F. L. ;

Cosimi, A. B. ;

Ko, D. S. C. .

AMERICAN JOURNAL OF TRANSPLANTATION, 2007, 7 (12) :2769-2774

[9] Comparison of mortality in all patients on dialysis, patients on dialysis awaiting transplantation, and recipients of a first cadaveric transplant. [J].

Wolfe, RA ;

Ashby, VB ;

Milford, EL ;

Ojo, AO ;

Ettenger, RE ;

Agodoa, LYC ;

Held, PJ ;

Port, FK .

NEW ENGLAND JOURNAL OF MEDICINE, 1999, 341 (23) :1725-1730

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