Complexation of synthetic CDM-AM copolymer with natamycin and carbendazim to improve solubility and fungicidal activity

被引：15
作者：
Li, Yong-Fu [1 ,2 ]
Ji, Jing [1 ,2 ]
Guo, Qin [1 ,2 ]
Ha, Yi-Ming [1 ,2 ]
Li, Qing-Peng [1 ,2 ]
机构：
[1] Chinese Acad Agr Sci, Inst Agroprod Proc Sci & Technol, Beijing 100193, Peoples R China
[2] Minist Agr, Key Opening Lab Agr Prod Proc & Qual Control, Beijing 100193, Peoples R China
来源：
CARBOHYDRATE POLYMERS | 2015年 / 125卷
关键词：
Natamycin; Carbendazim; Rheological properties; Solubility; Isothermal adsorption; Aspergillus niger; HYDROXYPROPYL-BETA-CYCLODEXTRIN; EPICHLOROHYDRIN POLYMERS; DRUG-RELEASE; IN-VITRO; DELIVERY; BEHAVIOR; SYSTEM;
D O I：
10.1016/j.carbpol.2015.02.055
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
The beta-cyclodextrin-acrylamide (CDM-AM) copolymer was prepared from acrylamide and beta-CD maleate (CDM) using K2S2O8 as initiator. The effects of the CDM-AM copolymer on the solubility and fungicidal activity of natamycin (NM) and carbendazim (MBC) were investigated. The stability constant of NM center dot CDM-AM and MBC center dot CDM-AM complexes at 303 K were of 10,725.45 M-1 and 3000.89 M-1, respectively. The complexes were characterized using phase solubility diagrams, NMR spectra and FT-IR spectra. The analysis of the biological activities of these two complexes indicated that they possessed enhancing fungicidal activities compared to NM and MBC alone. (C) 2015 Elsevier Ltd. All rights reserved.
引用
收藏
页码：288 / 300
页数：13
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